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Molecular Pharmacology, Vol 4, 201-207, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Oxidation of Indene in Liver Microsomes

KENNETH C. LEIBMAN 1 and ELSA ORTIZ 1

1 Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, Florida 32601

The oxidation of indene to trans-1,2-dihydroxyindane in liver preparations in vitro has been demonstrated. The reaction was mediated by liver microsomes of rats and rabbits in the presence of NADPH-generating systems. The oxidizing activity of the microsomes was markedly enhanced after pretreatment of the animals with phenobarbital. No cis-1,2-dihydroxyindane was found by methods which could have detected it at a level 0.5% of that of the trans-diol present in the reaction product. The cis-diol was not converted to its trans-isomer in the assay system. Indene epoxide was hydrated to trans-1,2-dihydroxyindane in the same in vitro system.

Note:
ACKNOWLEDGMENT This work was supported by U.S. Public Health Service Grant No. UI 00453 (formerly OH 00251).

Submitted on August 28, 1967
Revised on January 3, 1968






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