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Molecular Pharmacology, Vol 4, 288-292, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

The Binding of Noradrenaline to Monophosphoinositide: In Vitro Studies

BENT FORMBY 1

1 The Neurochemical Institute, Copenhagen, N, Denmark

Monophosphoinositide chromatographically purified from bovine brain extract shows in in vitro experiments a high capacity to bind noradrenaline. Using a simplified two-phase model consisting of an aqueous phase with noradrenaline and a lipophilic organic phase with monophosphoinositide, thermodynamic variables are calculated for the binding reaction. The binding capacity and the partition of lipid was strongly influenced by the presence of bivalent cations. From the results obtained a possible receptor function of monophosphoinositide for noradrenaline in synaptosomes is discussed.

Note:
ACKNOWLEDGMENT This work was supported by a grant from the Danish Epilepsy Association.

Submitted on November 27, 1967
Revised on February 13, 1968






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