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Molecular Pharmacology, Vol 4, 293-299, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Purine Nucleoside Phosphorylase from Human Erythrocytes III. Inhibition by the Inosine Analog Formycin B of the Isolated Enzyme and of Nucleoside Metabolism in Intact Erythrocytes and Sarcoma 180 Cells

M. R. SHEEN 1, BYUNG KYU KIM 1, and R. E. PARKS JR. 1

1 Division of Biological and Medical Sciences, Brown University, Providence, Rhode Island O2912

Formycin B, an analog of inosine, is a potent competitive inhibitor of purified erythrocytic purine nucleoside phosphorylase. The inhibition constant, Ki (1 x 10-4 M) is of the same order of magnitude as the Km for inosine (5 x 10-5 M). Formycin B also inhibits the degradation of nucleosides by intact and hemolyzed human erythrocytes and by Sarcoma 180 ascites cells.

Note:
ACKNOWLEDGMENT The authors would like to express their appreciation to Dr. Sungnan Cha for his help in the preparation of this manuscript.

Submitted on January 23, 1968




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I. Kazmers, B. Mitchell, P. Dadonna, L. Wotring, L. Townsend, and W. Kelley
Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts
Science, December 4, 1981; 214(4525): 1137 - 1139.
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