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Molecular Pharmacology, Vol 4, 427-434, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Induction of Leukemia and Ovarian Tumors in Mice by Pulse-Doses of Polycyclic Aromatic Hydrocarbons

KUNIO UEMATSU 1 and CHARLES HUGGINS 1

1 The Ben May Laboratory for Cancer Research, The University of Chicago, Illinois 60637

Pulse-doses of 7,12-dimethylbenz[a]anthracene and 7,8,12-trimethylbenz[a]anthracene share a remarkable ability to damage selectively endocrine glands and targets of hormones in female rodents. Both compounds depress synthesis of DNA in ileum and spleen.

In CF-1 mice, 7,12-dimethylbenz[a]anthracene and 7,8,12-trimethylbenz[a]anthracene severely injured the ovary and elicited ovarian tumors and leukemia, whereas the adrenal was uninjured by these compounds. 3-Methylcholanthrene and benzo[a]pyrene induced leukemia, but ovarian tumors did not develop.

In adult rats, a pulse-dose of 7,8,12-trimethylbenz[a]anthracene caused adrenal apoplexy but did not evoke ovarian tumors.

Note:
ACKNOWLEDGMENTS Lipid emulsions of hydrocarbons were prepared by P. E. Schurr, The Upjohn Company, Kalamazoo, Michigan. We are grateful to Eugene DeSombre, Ben May Laboratory for Cancer Research, The University of Chicago, for measurement of radioactivity.

Submitted on June 19, 1968






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