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Molecular Pharmacology, Vol 4, 457-464, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Increased Synthesis of Catecholamines in the Intact Rat following Administration of agr-Adrenergic Blocking Agents

WALLACE DAIRMAN 1, ROBERT GORDON 1, SYDNEY SPECTOR 1, ALBERT SJOERDSMA 1, and SIDNEY UDENFRIEND 1

1 Laboratory of Clinical Biochemistry and Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014

The present study was undertaken to evaluate the effects of agr-blocking agents on the rate of catecholamine synthesis in vivo. It was found that phentolamine and phenoxybenzamine increase the formation of radioactive norepinephrine and epinephrine in rat tissues when L-tyrosine-14C is used as a precursor but not when L-dopa-3H is the precursor. These findings indicate that agr-blocking agents increase catecholamine synthesis by stimulating tyrosine hydroxylase activity.

Submitted on April 9, 1968




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Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics