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Molecular Pharmacology, Vol 4, 541-548, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Mechanism of p-Nitrobenzoate Reduction in Liver: The Possible Role of Cytochrome P-450 in Liver Microsomes

JAMES R. GILLETTE 1, JEROME J. KAMM 1, and HENRY A. SASAME 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014

The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride.

Submitted on June 13, 1968




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