MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HOCHSTEIN, P.
Right arrow Articles by UTLEY, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by HOCHSTEIN, P.
Right arrow Articles by UTLEY, H.

Molecular Pharmacology, Vol 4, 574-579, Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics

Hydrogen Peroxide Detoxication by Glutathione Peroxidase and Catalase in Rat Liver Homogenates

PAUL HOCHSTEIN 1 and HENRY UTLEY 1

1 Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27706

The activity of glutathione peroxidase (H2O2:glutathione oxidoreductase, EC 1.11.1.9) has been studied in the soluble supernatant fractions prepared from rat liver homogenates. Enzyme activity may be demonstrated in the presence of active as well as inhibited catalase. The findings are compatible with an essential function for hepatic glutathione peroxidase in the detoxication of intracellular hydrogen peroxide, and with the view that hydrogen peroxide is the common toxic agent in the drug-induced anemia associated with a genetic deficiency of erythrocyte glucose 6-phosphate dehydrogenase. The experiments also suggest a potential role for glutathione peroxidase in regulating cellular metabolism via pentose shunt control.

Submitted on June 10, 1968






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1968 by the American Society for Pharmacology and Experimental Therapeutics