MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Helferich, W. G.
Right arrow Articles by Denison, M. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Helferich, W. G.
Right arrow Articles by Denison, M. S.

Ultraviolet photoproducts of tryptophan can act as dioxin agonists

WG Helferich and MS Denison

Department of Food Science and Human Nutrition, Michigan State University, East Lansing 48824-1224.

Tryptophan (TRP) has been implicated in the mechanism of induction of microsomal aryl hydrocarbon hydroxylase (AHH) activity by UV light. UV irradiation of TRP resulted in formation of chloroform-soluble photoproducts that can specifically bind to the Ah receptor (AhR), an intracellular protein that mediates the induction of AHH activity by xenobiotics. Gel retardation analysis revealed that the TRP photoproducts, like other AHH inducers, complex to its specific DNA recognition site. Transient transfection experiments also demonstrated that the photoproducts could induce gene expression in an AhR-dependent manner. Thus, induction of AHH activity by UV light could be attributed, at least in part, to the formation of TRP photoproducts, which appear to act as AhR ligands.

Volume 40, Issue 5, pp. 674-678, 11/01/1991
Copyright © 1991 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Toxicol SciHome page
M. Mukai and S. A. Tischkau
Effects of Tryptophan Photoproducts in the Circadian Timing System: Searching for a Physiological Role for Aryl Hydrocarbon Receptor
Toxicol. Sci., January 1, 2007; 95(1): 172 - 181.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. Diani-Moore, E. Labitzke, R. Brown, A. Garvin, L. Wong, and A. B. Rifkind
Sunlight Generates Multiple Tryptophan Photoproducts Eliciting High Efficacy CYP1A Induction in Chick Hepatocytes and In Vivo
Toxicol. Sci., March 1, 2006; 90(1): 96 - 110.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. A. Bittinger, L. P. Nguyen, and C. A. Bradfield
Aspartate Aminotransferase Generates Proagonists of the Aryl Hydrocarbon Receptor
Mol. Pharmacol., September 1, 2003; 64(3): 550 - 556.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. D. Seidel, V. Li, G. M. Winter, W. J. Rogers, E. I. Martinez, and M. S. Denison
Ah Receptor-Based Chemical Screening Bioassays: Application and Limitations for the Detection of Ah Receptor Agonists
Toxicol. Sci., May 1, 2000; 55(1): 107 - 115.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
V. Mastyugin, E. Aversa, A. Bonazzi, C. Vafaes, P. Mieyal, and M. L. Schwartzman
Hypoxia-Induced Production of 12-Hydroxyeicosanoids in the Corneal Epithelium: Involvement of a Cytochrome P-4504B1 Isoform
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1611 - 1619.
[Abstract] [Full Text]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1991 by the American Society for Pharmacology and Experimental Therapeutics