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Dynamic control of inositol 1,4,5-trisphosphate-induced Ca2+ release: a theoretical explanation for the quantal release of Ca2+

S Swillens

Institut de Recherche Interdisciplinaire, Universite Libre de Bruxelles, Belgium.

A theoretical model has been elaborated in order to describe the kinetics of Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3). The model is based on the existence of a key molecule that controls the interconversion of open and closed forms of the Ca2+ channel. The model can quantitatively explain the previously obtained experimental observations that showed that a continuous IP3 stimulus leads to a biphasic Ca2+ release and that successive IP3 additions provoke repetitive bursts of Ca2+ release. Other published interpretations of these observations are discussed.

Volume 41, Issue 1, pp. 110-114, 01/01/1992
Copyright © 1992 by American Society for Pharmacology and Experimental Therapeutics




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S Gyorke and M Fill
Ryanodine receptor adaptation: control mechanism of Ca(2+)-induced Ca2+ release in heart
Science, May 7, 1993; 260(5109): 807 - 809.
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Copyright © 1992 by the American Society for Pharmacology and Experimental Therapeutics