![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
D Bleakman, KI Rusin, PS Chard, SR Glaum and RJ Miller
Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637.
The effects of the metabotropic glutamate receptor agonist (1S,3R)-1- aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] were examined on responses mediated by the ionotropic glutamate receptor agonists N- methyl D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazole- propionic acid (AMPA), and kainic acid (KA), in neurons acutely isolated from the dorsal horn of the rat spinal cord. (1S,3R)-ACPD produced an increase in the intracellular Ca2+ concentration in 50% of acutely isolated dorsal horn neurons, which could be prevented by blockers of voltage-sensitive Ca2+ channels. (1S,3R)-ACPD markedly potentiated increases in the intracellular Ca2+ concentration induced by NMDA, AMPA, and KA but not by 10-50 mM KCl. This potentiation occurred in all cells, required the simultaneous presence of both agonists, and was rapidly reversible. In the spinal cord slice preparation, (1S,3R)-ACPD potentiated the inward currents evoked by pressure application of AMPA, NMDA, and KA, an effect that was also rapidly reversible. These short term effects of (1S,3R)-ACPD may play an important role in the regulation of ionotropic responses mediated by glutamate in the spinal cord.
This article has been cited by other articles:
|
|
 |
|
  H. Huang and A. N. van den Pol Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons J. Neurosci., October 24, 2007; 27(43): 11560 - 11572. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Gabra, F. K. Kessler, J. K. Ritter, W. L. Dewey, and F. L. Smith Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-Hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-Mediated Hyperalgesia J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 186 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Guo, F. Wei, S. Zou, M. T. Robbins, S. Sugiyo, T. Ikeda, J.-C. Tu, P. F. Worley, R. Dubner, and K. Ren Group I Metabotropic Glutamate Receptor NMDA Receptor Coupling and Signaling Cascade Mediate Spinal Dorsal Horn NMDA Receptor 2B Tyrosine Phosphorylation Associated with Inflammatory Hyperalgesia J. Neurosci., October 13, 2004; 24(41): 9161 - 9173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. R. Antunes, L. G. H. Bonagamba, and B. H. Machado NMDA receptor antagonism blocks the cardiovascular responses to microinjection of trans-ACPD into the NTS of awake rats Exp Physiol, May 1, 2004; 89(3): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Benquet, C. E. Gee, and U. Gerber Two Distinct Signaling Pathways Upregulate NMDA Receptor Responses via Two Distinct Metabotropic Glutamate Receptor Subtypes J. Neurosci., November 15, 2002; 22(22): 9679 - 9686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhang, Y. Lu, Y. Chen, and K. N. Westlund Group I Metabotropic Glutamate Receptor Antagonists Block Secondary Thermal Hyperalgesia in Rats with Knee Joint Inflammation J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Krieger, J. Hellgren-Kotaleski, P. Kettunen, and A. J. El Manira Interaction between Metabotropic and Ionotropic Glutamate Receptors Regulates Neuronal Network Activity J. Neurosci., July 15, 2000; 20(14): 5382 - 5391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Neugebauer, P.-S. Chen, and W. D. Willis Role of Metabotropic Glutamate Receptor Subtype mGluR1 in Brief Nociception and Central Sensitization of Primate STT Cells J Neurophysiol, July 1, 1999; 82(1): 272 - 282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Young, G. Blackburn-Munro, T. Dickinson, M. J. Johnson, H. Anderson, I. Nakalembe, and S. M. Fleetwood-Walker Antisense Ablation of Type I Metabotropic Glutamate Receptor mGluR1 Inhibits Spinal Nociceptive Transmission J. Neurosci., December 1, 1998; 18(23): 10180 - 10188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zirpel, W. R. Lippe, and E. W Rubel Activity-Dependent Regulation of [Ca2+]i in Avian Cochlear Nucleus Neurons: Roles of Protein Kinases A and C and Relation to Cell Death J Neurophysiol, May 1, 1998; 79(5): 2288 - 2302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Montoliu, M. Llansola, C. Cucarella, S. Grisolía, and V. Felipo Activation of the Metabotropic Glutamate Receptor mGluR5 Prevents Glutamate Toxicity in Primary Cultures of Cerebellar Neurons J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 643 - 647. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Gu and S. J. Publicover Expression of Functional Metabotropic Glutamate Receptors in Primary Cultured Rat Osteoblasts. CROSS-TALK WITH N-METHYL-D-ASPARTATE RECEPTORS J. Biol. Chem., October 27, 2000; 275(44): 34252 - 34259. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
