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Multiple sulfonylurea-sensitive potassium channels: a novel subtype modulated by dopamine

YJ Lin, GJ Greif and JE Freedman

Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115.

In single channel patch-clamp recordings from freshly dissociated rat corpus striatum (caudate-putamen) neurons, the sulfonylurea drugs tolbutamide and glibenclamide caused a concentration-dependent blockade of a K+ channel that is activated by D2 dopamine receptor agonists. Tolbutamide was about 10-100 times more potent than glibenclamide, a rank-order potency opposite to that seen at previously described adenosine triphosphate-sensitive K+ channels. The channel also was poorly activated by diazoxide, which is a known opener of adenosine triphosphate-sensitive K+ channels. However, like adenosine triphosphate-sensitive channels, it opened in the absence of dopaminergic agonist when the cells were treated with the metabolic inhibitor rotenone, indicating that channel openings occur under energy- depleting conditions. This suggests the existence of a novel, pharmacologically distinct class of sulfonyl-urea-sensitive K+ channels, regulated metabolically and also mediating dopaminergic neurotransmission.

Volume 44, Issue 5, pp. 907-910, 11/01/1993
Copyright © 1993 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1993 by the American Society for Pharmacology and Experimental Therapeutics