![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
AM Garland, EF Grady, M Lovett, SR Vigna, MM Frucht, JE Krause and NW Bunnett
Department of Surgery, University of California, San Francisco, 94143- 0660, USA.
We compared the desensitization of neurokinin1 and neurokinin2 (NK1 and NK2) receptors expressed in Chinese hamster ovary cells to substance P and neurokinin A, respectively. Substance P and neurokinin A stimulated a rapid increase in intracellular Ca2+ concentration ([Ca2+]i) for both receptors, which was due to release of Ca2+ from intracellular stores. This was followed by a plateau in [Ca2+]i, which was due to influx of extracellular Ca2+, and was more sustained for the NK2 receptor. When Ca2+ was present in the extracellular solution, the Ca2+ response of the NK1 receptor, but not the NK2 receptor, rapidly desensitized and slowly resensitized to two exposures to agonist. In contrast, the [Ca2+]i response, measured in Ca2+-free solution, and inositol triphosphate generation desensitized and resensitized similarly for the NK1 and NK2 receptors. Thus, differences in desensitization between the NK1 receptor and the NK2 receptor may be related to differences in entry of extracellular Ca2+. We compared endocytosis of the NK1 and NK2 receptors to determine whether disparities could account for differences in desensitization. Fluorescent and radiolabeled substance P and neurokinin A were internalized similarly by cells expressing NK1 and NK2 receptors. Thus, disparities in internalization cannot account for differences in desensitization. We used inhibitors to examine the contribution of endocytosis, recycling, and phosphatases to desensitization and resensitization of the NK1 receptor. Desensitization did not require endocytosis. However, resensitization required endocytosis, recycling, and phosphatase activity. This suggests that the NK1 receptor desensitizes by phosphorylation and resensitizes by dephosphorylation in endosomes and recycling.
This article has been cited by other articles:
|
|
 |
|
  B. E. Padilla, G. S. Cottrell, D. Roosterman, S. Pikios, L. Muller, M. Steinhoff, and N. W. Bunnett Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and -arrestins J. Cell Biol., December 3, 2007; 179(5): 981 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Roosterman, G. S. Cottrell, B. E. Padilla, L. Muller, C. B. Eckman, N. W. Bunnett, and M. Steinhoff Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling PNAS, July 10, 2007; 104(28): 11838 - 11843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Cottrell, B. Padilla, S. Pikios, D. Roosterman, M. Steinhoff, E. F. Grady, and N. W. Bunnett Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1 J. Biol. Chem., April 20, 2007; 282(16): 12260 - 12271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Gardner, S. J. Tavalin, A. S. Goehring, J. D. Scott, and S. W. Bahouth AKAP79-mediated Targeting of the Cyclic AMP-dependent Protein Kinase to the beta1-Adrenergic Receptor Promotes Recycling and Functional Resensitization of the Receptor J. Biol. Chem., November 3, 2006; 281(44): 33537 - 33553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Cottrell, B. Padilla, S. Pikios, D. Roosterman, M. Steinhoff, D. Gehringer, E. F. Grady, and N. W. Bunnett Ubiquitin-dependent Down-regulation of the Neurokinin-1 Receptor J. Biol. Chem., September 22, 2006; 281(38): 27773 - 27783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Engel, S. Neumann, N. Kaur, V. Monga, R. Jain, J. Northup, and M. C. Gershengorn Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists J. Biol. Chem., May 12, 2006; 281(19): 13103 - 13109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J Wong, N. J Tublitz, and C. T Minson Neurokinin-1 receptor desensitization to consecutive microdialysis infusions of substance P in human skin J. Physiol., November 1, 2005; 568(3): 1047 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Vazquez, I. Roncero, E. Blazquez, and E. Alvarez The cytoplasmic domain close to the transmembrane region of the glucagon-like peptide-1 receptor contains sequence elements that regulate agonist-dependent internalisation J. Endocrinol., July 1, 2005; 186(1): 221 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. J. Bennett, S. A. Perrine, and M. A. Simmons Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling J. Pharmacol. Exp. Ther., June 1, 2005; 313(3): 1347 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Paasche, T. Attramadal, K. Kristiansen, M. P. Oksvold, H. K. Johansen, H. S. Huitfeldt, S. G. Dahl, and H. Attramadal Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors Mol. Pharmacol., May 1, 2005; 67(5): 1581 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Hassan and D Mason Mechanisms of desensitization of the adrenocorticotropin response to arginine vasopressin in ovine anterior pituitary cells J. Endocrinol., January 1, 2005; 184(1): 29 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Heydorn, B. P. Sondergaard, B. Ersboll, B. Holst, F. C. Nielsen, C. R. Haft, J. Whistler, and T. W. Schwartz A Library of 7TM Receptor C-terminal Tails: INTERACTIONS WITH THE PROPOSED POST-ENDOCYTIC SORTING PROTEINS ERM-BINDING PHOSPHOPROTEIN 50 (EBP50), N-ETHYLMALEIMIDE-SENSITIVE FACTOR (NSF), SORTING NEXIN 1 (SNX1), AND G PROTEIN-COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN (GASP) J. Biol. Chem., December 24, 2004; 279(52): 54291 - 54303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cezanne, S. Lecat, B. Lagane, C. Millot, J.-Y. Vollmer, H. Matthes, J.-L. Galzi, and A. Lopez Dynamic Confinement of NK2 Receptors in the Plasma Membrane: IMPROVED FRAP ANALYSIS AND BIOLOGICAL RELEVANCE J. Biol. Chem., October 22, 2004; 279(43): 45057 - 45067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Roosterman, G. S. Cottrell, F. Schmidlin, M. Steinhoff, and N. W. Bunnett Recycling and Resensitization of the Neurokinin 1 Receptor: INFLUENCE OF AGONIST CONCENTRATION AND Rab GTPASES J. Biol. Chem., July 16, 2004; 279(29): 30670 - 30679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Gardner, N. M. D. Santos, S. G. Matta, M. A. Whitt, and S. W. Bahouth Role of the Cyclic AMP-dependent Protein Kinase in Homologous Resensitization of the {beta}1-Adrenergic Receptor J. Biol. Chem., May 14, 2004; 279(20): 21135 - 21143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. W. Tawfeek and A. B. Abou-Samra Important role for the V-type H+-ATPase and the Golgi apparatus in the recycling of PTH/PTHrP receptor Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E704 - E710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Schmidlin, D. Roosterman, and N. W. Bunnett The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with {beta}-arrestins Am J Physiol Cell Physiol, October 1, 2003; 285(4): C945 - C958. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Shafer, V. J. Bennett, P. Kim, and J. C. Voss Probing the Binding Pocket and Endocytosis of a G Protein-coupled Receptor in Live Cells Reported by a Spin-labeled Substance P Agonist J. Biol. Chem., September 5, 2003; 278(36): 34203 - 34210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Roosterman, F. Schmidlin, and N. W. Bunnett Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2 Am J Physiol Cell Physiol, May 1, 2003; 284(5): C1319 - C1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. J. Bennett, S. A. Perrine, and M. A. Simmons A Novel Mechanism of Neurokinin-1 Receptor Resensitization J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chauvin, M. Bencsik, T. Bambino, and R. A. Nissenson Parathyroid Hormone Receptor Recycling: Role of Receptor Dephosphorylation and {beta}-Arrestin Mol. Endocrinol., December 1, 2002; 16(12): 2720 - 2732. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Ma, H.-S. Huang, C.-T. Chien, M.-S. Wu, and C.-F. Chen Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct Am J Physiol Renal Physiol, July 1, 2002; 283(1): F164 - F172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Duffy, G. B. Varty, C. A. Morgan, and J. E. Lachowicz Correlation of Neurokinin (NK) 1 Receptor Occupancy in Gerbil Striatum with Behavioral Effects of NK1 Antagonists J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 536 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Schmidlin, O. Dery, N. W. Bunnett, and E. F. Grady Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta -Arrestin-dependent interactions between neurokinin receptors PNAS, March 5, 2002; 99(5): 3324 - 3329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Bradesi, H Eutamene, J Fioramonti, and L Bueno Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids Gut, March 1, 2002; 50(3): 349 - 354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Dery, K. A. Defea, and N. W. Bunnett Protein kinase C-mediated desensitization of the neurokinin 1 receptor Am J Physiol Cell Physiol, May 1, 2001; 280(5): C1097 - C1106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Coutts, S. Anavi-Goffer, R. A. Ross, D. J. MacEwan, K. Mackie, R. G. Pertwee, and A. J. Irving Agonist-Induced Internalization and Trafficking of Cannabinoid CB1 Receptors in Hippocampal Neurons J. Neurosci., April 1, 2001; 21(7): 2425 - 2433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. G. Ferguson Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling Pharmacol. Rev., March 1, 2001; 53(1): 1 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. H. Anborgh, J. L. Seachrist, L. B. Dale, and S. S. G. Ferguson Receptor/{beta}-Arrestin Complex Formation and the Differential Trafficking and Resensitization of {beta}2-Adrenergic and Angiotensin II Type 1A Receptors Mol. Endocrinol., December 1, 2000; 14(12): 2040 - 2053. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Yu, L. D. Asico, G. M. Eisner, U. Hopfer, R. A. Felder, and P. A. Jose Renal Protein Phosphatase 2A Activity and Spontaneous Hypertension in Rats Hypertension, December 1, 2000; 36(6): 1053 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Maa, E. F. Grady, E. H. Kim, S. K. Yoshimi, M. M. Hutter, N. W. Bunnett, and K. S. Kirkwood NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation Am J Physiol Gastrointest Liver Physiol, October 1, 2000; 279(4): G726 - G732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Oakley, S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron Association of beta -Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization J. Biol. Chem., November 5, 1999; 274(45): 32248 - 32257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Trafton, C. Abbadie, S. Marchand, P. W. Mantyh, and A. I. Basbaum Spinal Opioid Analgesia: How Critical Is the Regulation of Substance P Signaling? J. Neurosci., November 1, 1999; 19(21): 9642 - 9653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Willars, A. Heding, M. Vrecl, R. Sellar, M. Blomenrohr, S. R. Nahorski, and K. A. Eidne Lack of a C-terminal Tail in the Mammalian Gonadotropin-releasing Hormone Receptor Confers Resistance to Agonist-dependent Phosphorylation and Rapid Desensitization J. Biol. Chem., October 15, 1999; 274(42): 30146 - 30153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sturiale, G. Barbara, B. Qiu, M. Figini, P. Geppetti, N. Gerard, C. Gerard, E. F. Grady, N. W. Bunnett, and S. M. Collins Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P PNAS, September 28, 1999; 96(20): 11653 - 11658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Sarret, D. Nouel, C. Dal Farra, J.-P. Vincent, A. Beaudet, and J. Mazella Receptor-mediated Internalization Is Critical for the Inhibition of the Expression of Growth Hormone by Somatostatin in the Pituitary Cell Line AtT-20 J. Biol. Chem., July 2, 1999; 274(27): 19294 - 19300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Dery, M. S. Thoma, H. Wong, E. F. Grady, and N. W. Bunnett Trafficking of Proteinase-activated Receptor-2 and beta -Arrestin-1 Tagged with Green Fluorescent Protein. beta -ARRESTIN-DEPENDENT ENDOCYTOSIS OF A PROTEINASE RECEPTOR J. Biol. Chem., June 25, 1999; 274(26): 18524 - 18535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. McConalogue, O. Dery, M. Lovett, H. Wong, J. H. Walsh, E. F. Grady, and N. W. Bunnett Substance P-induced Trafficking of beta -Arrestins. THE ROLE OF beta -ARRESTINS IN ENDOCYTOSIS OF THE NEUROKININ-1 RECEPTOR J. Biol. Chem., June 4, 1999; 274(23): 16257 - 16268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. D. Roush, K. Warabi, and M. M. Kwatra Characterization of Differences Between Rapid Agonist-Dependent Phosphorylation and Phorbol Ester-Mediated Phosphorylation of Human Substance P Receptor in Intact Cells Mol. Pharmacol., May 1, 1999; 55(5): 855 - 862. [Abstract] [Full Text]
|
|
|
|
|
|
L. S. Barak, K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra Real-time Visualization of the Cellular Redistribution of G Protein-coupled Receptor Kinase 2 and beta -Arrestin 2 during Homologous Desensitization of the Substance P Receptor J. Biol. Chem., March 12, 1999; 274(11): 7565 - 7569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Allen, J. Li, P. M. Menning, S. D. Rogers, J. Ghilardi, P. W. Mantyh, and D. A. Simone Primary Afferent Fibers That Contribute to Increased Substance P Receptor Internalization in the Spinal Cord After Injury J Neurophysiol, March 1, 1999; 81(3): 1379 - 1390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dietrich, T. Backstrom, J. P. H. Lauritsen, J. Kastrup, M. D. Christensen, F. von Bulow, E. Palmer, and C. Geisler The Phosphorylation State of CD3gamma Influences T Cell Responsiveness and Controls T Cell Receptor Cycling J. Biol. Chem., September 11, 1998; 273(37): 24232 - 24238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Kramer, N. Cutler, J. Feighner, R. Shrivastava, J. Carman, J. J. Sramek, S. A. Reines, G. Liu, D. Snavely, E. Wyatt-Knowles, et al. Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors Science, September 11, 1998; 281(5383): 1640 - 1645. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. McConalogue, C. U. Corvera, P. D. Gamp, E. F. Grady, and N. W. Bunnett Desensitization of the Neurokinin-1 Receptor (NK1-R) in Neurons: Effects of Substance P on the Distribution of NK1-R, Galpha q/11, G-Protein Receptor Kinase-2/3, and beta -Arrestin-1/2 Mol. Biol. Cell, August 1, 1998; 9(8): 2305 - 2324. [Abstract] [Full Text]
|
|
|
|
|
|
C. A. Saura, J. Mallol, E. I. Canela, C. Lluis, and R. Franco Adenosine Deaminase and A1 Adenosine Receptors Internalize Together following Agonist-induced Receptor Desensitization J. Biol. Chem., July 10, 1998; 273(28): 17610 - 17617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Sanders IV. Neural regulation of gastrointestinal smooth muscle Am J Physiol Gastrointest Liver Physiol, July 1, 1998; 275(1): G1 - G7. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Eckersell, P. Popper, and P. E Micevych Estrogen-Induced Alteration of µ-Opioid Receptor Immunoreactivity in the Medial Preoptic Nucleus and Medial Amygdala J. Neurosci., May 15, 1998; 18(10): 3967 - 3976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Gembitsky, S. Lovas, and R. F. Murphy Development of a High Throughput Functional Assay for Structure-Activity Studies of Neurokinin A Analogs J Biomol Screen, April 1, 1998; 3(3): 183 - 188. [Abstract] [PDF]
|
|
|
|
|
|
D. E. Keith, B. Anton, S. R. Murray, P. A. Zaki, P. C. Chu, D. V. Lissin, G. Monteillet-Agius, P. L. Stewart, C. J. Evans, and M. v. Zastrow µ-Opioid Receptor Internalization: Opiate Drugs Have Differential Effects on a Conserved Endocytic Mechanism In Vitro and in the Mammalian Brain Mol. Pharmacol., March 1, 1998; 53(3): 377 - 384. [Abstract] [Full Text]
|
|
|
|
|
|
N. Signoret, J. Oldridge, A. Pelchen-Matthews, P. J. Klasse, T. Tran, L. F. Brass, M. M. Rosenkilde, T. W. Schwartz, W. Holmes, W. Dallas, et al. Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4 J. Cell Biol., November 3, 1997; 139(3): 651 - 664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. G. Marvizon, V. Martinez, E. F. Grady, N. W. Bunnett, and E. A. Mayer Neurokinin 1 Receptor Internalization in Spinal Cord Slices Induced by Dorsal Root Stimulation Is Mediated by NMDA Receptors J. Neurosci., November 1, 1997; 17(21): 8129 - 8136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, L. S. Barak, K. E. Winkler, M. G. Caron, and S. S. G. Ferguson A Central Role for beta -Arrestins and Clathrin-coated Vesicle-mediated Endocytosis in beta 2-Adrenergic Receptor Resensitization. DIFFERENTIAL REGULATION OF RECEPTOR RESENSITIZATION IN TWO DISTINCT CELL TYPES J. Biol. Chem., October 24, 1997; 272(43): 27005 - 27014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Weinreich, K. A. Moore, and G. E. Taylor Allergic Inflammation in Isolated Vagal Sensory Ganglia Unmasks Silent NK-2 Tachykinin Receptors J. Neurosci., October 15, 1997; 17(20): 7683 - 7693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, S. E. Leeman, B. E. Slack, G. Hauser, W. S. Saltsman, J. E. Krause, J. K. Blusztajn, and N. D. Boyd A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization PNAS, August 19, 1997; 94(17): 9475 - 9480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Kong, K. McConalogue, L. M. Khitin, M. D. Hollenberg, D. G. Payan, S. K. Bohm, and N. W. Bunnett Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2 PNAS, August 5, 1997; 94(16): 8884 - 8889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Allen, S. D. Rogers, J. R. Ghilardi, P. M. Menning, M. A. Kuskowski, A. I. Basbaum, D. A. Simone, and P. W. Mantyh Noxious Cutaneous Thermal Stimuli Induce a Graded Release of Endogenous Substance P in the Spinal Cord: Imaging Peptide Action In Vivo J. Neurosci., August 1, 1997; 17(15): 5921 - 5927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Solari, R. E. Offord, S. Remy, J.-P. Aubry, T. N.C. Wells, E. Whitehorn, T. Oung, and A. E.I. Proudfoot Receptor-mediated Endocytosis of CC-chemokines J. Biol. Chem., April 11, 1997; 272(15): 9617 - 9620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Bohm, L. M. Khitin, S. P. Smeekens, E. F. Grady, D. G. Payan, and N. W. Bunnett Identification of Potential Tyrosine-containing Endocytic Motifs in the Carboxyl-tail and Seventh Transmembrane Domain of the Neurokinin 1Receptor J. Biol. Chem., January 24, 1997; 272(4): 2363 - 2372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Schneider and A. Spradling The Drosophila G-protein-coupled receptor kinase homologue Gprk2 is required for egg morphogenesis Development, January 7, 1997; 124(13): 2591 - 2602. [Abstract] [PDF]
|
|
|
|
|
|
K. M. Krueger, Y. Daaka, J. A. Pitcher, and R. J. Lefkowitz The Role of Sequestration in G Protein-coupled Receptor Resensitization. REGULATION OF beta 2-ADRENERGIC RECEPTOR DEPHOSPHORYLATION BY VESICULAR ACIDIFICATION J. Biol. Chem., January 3, 1997; 272(1): 5 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Nouel, G |
