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Molecular Pharmacology, Vol 5, 286-293, Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics

The Effect of Organic and Inorganic Cations on the Decarbamylation of Dimethylcarbamylacetylcholinesterase: A Comparison with Deacetylation

B. D. ROUFOGALIS 1 and J. THOMAS 1

1 Department of Pharmacy, University of Sydney, Sydney, New South Wales, 2006, Australia

The effects of quaternary ammonium compounds and inorganic ions on the decarbamylation of dimethylcarbamylacetylcholinesterase at low ionic strength have been investigated. Both similarities and differences between the effects of these compounds on deacetylation and decarbamylation have been noted. Small quaternary ammonium compounds, such as tetraethylammonium and cis-2,6-dimethylspiro(piperidine-1,1'-pyrrolidinium) bromide, accelerate decarbamylation, an effect which has also been observed with deacetylation. Larger quaternary ammonium compounds, such as tetrapropylammonium, have no effect. on decarbamylation, whereas these compounds block deacetylation. Diethyldi(2-hydroxyethyl)ammonium iodide accelerates decarbamylation 71-fold, whereas this compound has a small inhibitory effect on deacetylation. NaCl and MgCl2 accelerate decarbamylation, and organic and inorganic cations compete for the carbamylated enzyme. Different protein conformations of acetyl- and dimethylcarbamylacetylcholinesterase have been suggested.

Submitted on October 25, 1968




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