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Molecular Pharmacology, Vol 5, 333-341, Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics

Passive Permeation of Organic Compounds through Biological Tissue: a Non-Steady-State Theory

JOHN T. PENNISTON 1, LAUREL BECKETT 1, DONALD L. BENTLEY 1, and CORWIN HANSCH 1

1 Departments of Chemistry and Mathematics, Pomona College, Claremont, California 91711

A theoretical analysis of the penetration of drug molecules to their sites of action in terms of their lipophilic character is presented. This analysis justifies the parabolic equations which have been used empirically to describe the relationship between effectiveness of drug and its lipophilic character.

Note:
ACKNOWLEDGMENTS We wish to thank Roger Smith for extensive advice and help in computer programming, and Dr. E. F. Korman for helpful advice on the manuscript. We are indebted to Miss C. Church for measuring the partition coefficient of trimethyl phosphate.

Submitted on March 8, 1969






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