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Molecular Pharmacology, Vol 5, 470-480, Copyright © 1969 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition of Estrogen-Induced Elevation of Cyclic 3',5'-Adenosine Monophosphate in Rat Uterus

I. By Beta-Adrenergic Receptor-Blocking Drugs

CLARA M. SZEGO 1 and JUNE S. DAVIS 1

1 Department of Zoology and The Molecular Biology Institute, University of California, Los Angeles, California 90024

The elevation of cyclic 3',5'-AMP which occurs in the uterus of the ovariectomized rat within 30 sec following intravenous administration of estradiol-17beta is subject to blockade by immediately prior injection by vein of the beta-adrenergic antagonists propranolol and, to a lesser extent, dichloroisoproterenol. Propranolol exhibited a slight agonistic effect, not hitherto recognized by other criteria; dichloroisoproterenol possessed this capacity to a striking degree, as had been anticipated. Bilateral adrenalectomy virtually abolished the inhibitory effect of dichloroisoproterenol on the response to estradiol-17beta while interfering only slightly with that due to propranolol. The alpha-adrenergic blocking agents phentolamine and dibenzyline appeared inert by these criteria.

These data constitute the first observations correlating the effects of systemically administered adrenergic blocking agents with the cyclic 3',5'-AMP response to estrogen in time intact uterus, and appear to support the suggestion that "beta-receptor" function may be closely associated with time the adenyl cyclase system.

Note:
ACKNOWLEDGMENTS The loyal and competent assistance of Kathleen Furamura and Amy Uyematsu in every phase of the glassware preparation is gratefully acknowledged. Thanks are extended to Edgar Kleiner, Richard Huber, and James Previdi for skilled animal care.

Submitted on November 25, 1968
Revised on April 30, 1969




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R. L. Singhal, R. Vijayvargiya, and G. M. Ling
Cyclic Adenosine Monophosphate: Andromimetic Action on Seminal Vesicular Enzymes
Science, April 10, 1970; 168(3928): 261 - 263.
[Abstract] [PDF]


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