![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
SR Glaum, M Hara, VP Bindokas, CC Lee, KS Polonsky, GI Bell and RJ Miller
Department of Pharmacological and Physiological Sciences, University of Chicago, Illinois 60637, USA.
We examined the effects of leptin, the product of the obese gene, on synaptic transmission in the arcuate nucleus in rat hypothalamic slices. Both leptin and neuropeptide Y (NPY) reduced the evoked glutamatergic excitatory postsynaptic current in the arcuate nucleus. NPY also depressed the GABAergic inhibitory postsynaptic current, although leptin had no effect. Leptin also decreased the input resistance of arcuate neurons, and this was accompanied by the activation of an outward current at depolarized potentials. Leptin modulated Ca2+ signals in acutely isolated arcuate neurons. In some cells, the intracellular calcium concentration rise produced by 50 mM K+ was decreased, whereas in others it was increased. However, leptin produced no effects on synaptic transmission and little or no effect on Ca2+ signaling in the hypothalamus of Zucker fatty rats that contain mutated leptin receptors. On the other hand, NPY exhibited synaptic modulatory effects in Zucker lean and fatty rats. These data suggest that leptin can produce rapid synaptic modulatory effects in the arcuate nucleus, which may contribute to its effects on food intake.
This article has been cited by other articles:
|
|
 |
|
  J. H. Peters, S. M. Simasko, and R. C. Ritter Leptin Analog Antagonizes Leptin Effects on Food Intake and Body Weight but Mimics Leptin-Induced Vagal Afferent Activation Endocrinology, June 1, 2007; 148(6): 2878 - 2885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. W. Williams, A. Zsombok, and B. N. Smith Rapid Inhibition of Neurons in the Dorsal Motor Nucleus of the Vagus by Leptin Endocrinology, April 1, 2007; 148(4): 1868 - 1881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Dong, J. P. Tyszkiewicz, and T. M. Fong Galanin and Galanin-Like Peptide Differentially Modulate Neuronal Activities in Rat Arcuate Nucleus Neurons J Neurophysiol, May 1, 2006; 95(5): 3228 - 3234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bjorbaek and B. B. Kahn Leptin Signaling in the Central Nervous System and the Periphery Recent Prog. Horm. Res., January 1, 2004; 59(1): 305 - 331. [Abstract] [Full Text]
|
|
|
|
 |
|
 I. Swart, J. W. Jahng, J. M. Overton, and T. A. Houpt Hypothalamic NPY, AGRP, and POMC mRNA responses to leptin and refeeding in mice Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1020 - R1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. H. van Dielen, C. van 't Veer, W. A. Buurman, and J. W. M. Greve Leptin and Soluble Leptin Receptor Levels in Obese and Weight-Losing Individuals J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1708 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pronchuk, A. G. Beck-Sickinger, and W. F. Colmers Multiple NPY Receptors Inhibit GABAA Synaptic Responses of Rat Medial Parvocellular Effector Neurons in the Hypothalamic Paraventricular Nucleus Endocrinology, February 1, 2002; 143(2): 535 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Ivanov and A. A. Romanovsky Fever responses of Zucker rats with and without fatty mutation of the leptin receptor Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R311 - R316. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kalsbeek, E. Fliers, J. A. Romijn, S. E. la Fleur, J. Wortel, O. Bakker, E. Endert, and R. M. Buijs The Suprachiasmatic Nucleus Generates the Diurnal Changes in Plasma Leptin Levels Endocrinology, June 1, 2001; 142(6): 2677 - 2685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Overton, T. D. Williams, J. B. Chambers, and M. E. Rashotte Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1007 - R1015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Marks, N. Ling, and R. D. Cone Role of the Central Melanocortin System in Cachexia Cancer Res., February 1, 2001; 61(4): 1432 - 1438. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Jang, A. Mistry, A. G. Swick, and D. R. Romsos Leptin Rapidly Inhibits Hypothalamic Neuropeptide Y Secretion and Stimulates Corticotropin-Releasing Hormone Secretion in Adrenalectomized Mice J. Nutr., November 1, 2000; 130(11): 2813 - 2820. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kawai, K. Sugimoto, K. Nakashima, H. Miura, and Y. Ninomiya Leptin as a modulator of sweet taste sensitivities in mice PNAS, September 19, 2000; (2000) 190066697. [Abstract] [Full Text]
|
|
|
|
|
|
K. Matsumura, I. Abe, T. Tsuchihashi, and M. Fujishima Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1314 - R1320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Iqbal, S. Pompolo, R. V. Considine, and I. J. Clarke Localization of Leptin Receptor-Like Immunoreactivity in the Corticotropes, Somatotropes, and Gonadotropes in the Ovine Anterior Pituitary Endocrinology, April 1, 2000; 141(4): 1515 - 1520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bergendahl, A. Iranmanesh, W. S. Evans, and J. D. Veldhuis Short-Term Fasting Selectively Suppresses Leptin Pulse Mass and 24-Hour Rhythmic Leptin Release in Healthy Midluteal Phase Women without Disturbing Leptin Pulse Frequency or Its Entropy Control (Pattern Orderliness) J. Clin. Endocrinol. Metab., January 1, 2000; 85(1): 207 - 213. [Abstract] [Full Text]
|
|
|
|
 |
|
 C.-S. Yuan, A. S. Attele, J. A. Wu, L. Zhang, and Z. Q. Shi Peripheral gastric leptin modulates brain stem neuronal activity in neonates Am J Physiol Gastrointest Liver Physiol, September 1, 1999; 277(3): G626 - G630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Ahima, C. Bjorbaek, S. Osei, and J. S. Flier Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development Endocrinology, June 1, 1999; 140(6): 2755 - 2762. [Abstract] [Full Text]
|
|
|
|
|
|
L. Sun and R. J. Miller Multiple Neuropeptide Y Receptors Regulate K+ and Ca2+ Channels in Acutely Isolated Neurons From the Rat Arcuate Nucleus J Neurophysiol, March 1, 1999; 81(3): 1391 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shaarawy and S. Y. El-Mallah Leptin and Gestational Weight Gain: Relation of Maternal and Cord Blood Leptin to Birth Weight Reproductive Sciences, March 1, 1999; 6(2): 70 - 73. [Abstract] [PDF]
|
|
|
|
|
|
M. Bergendahl, W. S. Evans, C. Pastor, A. Patel, A. Iranmanesh, and J. D. Veldhuis Short-Term Fasting Suppresses Leptin and (Conversely) Activates Disorderly Growth Hormone Secretion in Midluteal Phase Women--A Clinical Research Center Study J. Clin. Endocrinol. Metab., March 1, 1999; 84(3): 883 - 894. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. P. Kalra, M. G. Dube, S. Pu, B. Xu, T. L. Horvath, and P. S. Kalra Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight Endocr. Rev., February 1, 1999; 20(1): 68 - 100. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Soderberg, B. Ahren, B. Stegmayr, O. Johnson, P.-G. Wiklund, L. Weinehall, G. Hallmans, and T. Olsson Leptin Is a Risk Marker for First-Ever Hemorrhagic Stroke in a Population-Based Cohort Stroke, February 1, 1999; 30(2): 328 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Tankersley, C. O'Donnell, M. J. Daood, J. F. Watchko, W. Mitzner, A. Schwartz, and P. Smith Leptin attenuates respiratory complications associated with the obese phenotype J Appl Physiol, December 1, 1998; 85(6): 2261 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kotz, J. E. Briggs, J. D. Pomonis, M. K. Grace, A. S. Levine, and C. J. Billington Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R478 - R484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Kinney, P. J. Emmerson, and R. J. Miller Galanin Receptor-Mediated Inhibition of Glutamate Release in the Arcuate Nucleus of the Hypothalamus J. Neurosci., May 15, 1998; 18(10): 3489 - 3500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Powis, J. S. Bains, and A. V. Ferguson Leptin depolarizes rat hypothalamic paraventricular nucleus neurons Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1468 - R1472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Licinio, A. B. Negrao, C. Mantzoros, V. Kaklamani, M.-L. Wong, P. B. Bongiorno, A. Mulla, L. Cearnal, J. D. Veldhuis, J. S. Flier, et al. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women PNAS, March 3, 1998; 95(5): 2541 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Sun, L. H. Philipson, and R. J. Miller Regulation of K+ and Ca++ Channels by a Family of Neuropeptide Y Receptors J. Pharmacol. Exp. Ther., February 1, 1998; 284(2): 625 - 632. [Abstract] [Full Text]
|
|
|
|
 |
|
 T. M. Fong, R.-R. C. Huang, M. R. Tota, C. Mao, T. Smith, J. Varnerin, V. V. Karpitskiy, J. E. Krause, and L. H. T. Van der Ploeg Localization of Leptin Binding Domain in the Leptin Receptor Mol. Pharmacol., February 1, 1998; 53(2): 234 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Mistry, A. G. Swick, and D. R. Romsos Leptin Rapidly Lowers Food Intake and Elevates Metabolic Rates in Lean and ob/ob Mice J. Nutr., October 1, 1997; 127(10): 2065 - 2072. [Abstract] [Full Text]
|
|
|
|
|
|
M. L. Heiman, R. S. Ahima, L. S. Craft, B. Schoner, T. W. Stephens, and J. S. Flier Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress Endocrinology, September 1, 1997; 138(9): 3859 - 3863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Spicer and C. C. Francisco The Adipose Obese Gene Product, Leptin: Evidence of a Direct Inhibitory Role in Ovarian Function Endocrinology, August 1, 1997; 138(8): 3374 - 3379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Devos, Y. Guisez, J. Van der Heyden, D. W. White, M. Kalai, M. Fountoulakis, and G. Plaetinck Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding J. Biol. Chem., July 18, 1997; 272(29): 18304 - 18310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Legradi, C. H. Emerson, R. S. Ahima, J. S. Flier, and R. M. Lechan Leptin Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Messenger Ribonucleic Acid in Neurons of the Hypothalamic Paraventricular Nucleus Endocrinology, June 1, 1997; 138(6): 2569 - 2576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Rhim, G. A. Kinney, P. J. Emmerson, and R. J. Miller Regulation of Neurotransmission in the Arcuate Nucleus of the Rat by Different Neuropeptide Y Receptors J. Neurosci., May 1, 1997; 17(9): 2980 - 2989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawai, K. Sugimoto, K. Nakashima, H. Miura, and Y. Ninomiya Leptin as a modulator of sweet taste sensitivities in mice PNAS, September 26, 2000; 97(20): 11044 - 11049. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
