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Vol. 53, Issue 4, 597-601, April 1998
Pharmacogenetics Section, Laboratory of Reproductive and
Developmental Toxicology, National Institute of Environmental Health
Sciences, National Institutes of Health, Research Triangle Park, North
Carolina 27709
By extending previous studies of the phenobarbital (PB)-responsive
132-base pair (bp) enhancer sequence in the CYP2B10
gene, we have delimited a 51-bp enhancer element that is fully
inducible by PB in mouse primary hepatocytes. Sixteen structurally
unrelated phenobarbital-type inducers activated the 51-bp enhancer
element in transient transfection assays. The results thus indicate
that most PB-type inducers, if not all inducers, increase the
transcription of the CYP2B10 gene by activating this
51-bp element, now designated PB-responsive enhancer module or PBREM.
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