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Vol. 55, Issue 3, 444-452, March 1999
-Aminobutyric AcidA Receptor Pharmacological Properties
Departments of
Neurology (J.K., R.L.M.) and
Physiology (R.L.M.),
University of Michigan Medical Center, Ann Arbor, Michigan
Postnatal development of hippocampal dentate granule cell
-aminobutyric acidA (GABAA) receptor
pharmacological properties was studied. Granule cells were acutely
isolated from hippocampi of 7- to 14- and 45- to 52-day-old rats, and
whole cell patch-clamp recordings were obtained. The sensitivity of
GABAA receptors to GABA and modulation of GABAA
receptor currents by benzodiazepines (BZ), zinc, furosemide, and
loreclezole was studied. Multiple changes in the pharmacological
properties of dentate granule-cell GABAA receptors occurred
during the first 52 days of postnatal development: GABA-evoked maximal
current increased with postnatal age; GABAA receptors
changed from BZ type 3 in young rats to BZ type 1 in adult rats;
furosemide and zinc inhibited GABAA receptor currents in
young rats but not in adult rats; the fraction of cells that expressed
loreclezole-sensitive GABAA receptors increased with
postnatal age. These findings suggest that dentate granule cells in
young and adult animals express pharmacologically distinct GABAA receptors and that the postnatal development of these
receptors is prolonged, lasting at least 45 days. Comparison with the
previously reported pharmacological properties of GABAA
receptors on dentate granule cells acutely isolated from hippocampi of
28- to 35-day-old rats suggests that receptors expressed at that age
have properties intermediate between young and adult rats.
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