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Vol. 56, Issue 2, 396-403, August 1999
The Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering
Cancer Center, New York, New York
We have identified four new µ-opiod receptor
(MOR)-1 exons, indicating that the
gene now contains at least nine exons spanning more than 200 kilobases.
Replacement of exon 4 by combinations of the new exons yields three new
receptors. When expressed in Chinese hamster ovary cells, all three
variants displayed high affinity for µ-opioid ligands, but 
and
drugs were inactive. However, there were subtle, but
significant, differences in the binding profiles of the three variants
among themselves and from MOR-1. Immunohistochemically, the
major variant, MOR-1C, displayed a regional distribution
quite distinct from that of MOR-1. Region-specific processing also was seen at the mRNA level. Antisense mapping revealed
that the four new exons were all involved in morphine analgesia.
Together with two other variants generated from alternative splicing of
exon 4, there are now six distinct MOR-1 receptors.
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