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Vol. 58, Issue 6, 1188-1196, December 2000
Department of Pharmacology, Neurosciences Program, School of
Medicine, University of California, San Diego, La Jolla, California
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with
diverse physiological actions on many cell types. LPA induces
proliferative and/or morphological effects and has been proposed to be
involved in biologically important processes including neurogenesis,
myelination, angiogenesis, wound healing, and cancer progression. LPA
acts through specific G protein-coupled, seven-transmembrane domain
receptors. To date, three mammalian cognate receptor genes, lpA1/vzg-1/Edg2,
lpA2/Edg4, and
lpA3/Edg7, have been
identified that encode high-affinity LPA receptors. Here, we review
current knowledge on these LPA receptors, including their isolation,
function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.
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