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Molecular Pharmacology, Vol 6, 345-349, Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics

Altered Glycosidase Levels in Drug-Resistant Mouse Leukemias

H. BRUCE BOSMANN 1 and DAVID KESSEL 1

1 Department of Pharmacology and Toxicology and Division of Oncology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620

Sublines of transplantable mouse leukemias made resistant to actinomycin D, vincristine, and related antitumor agents show reduced levels of 10 glycosidases when compared with parent cell lines. Since glycosidases may be involved in the metabolism of membrane glycoproteins, resistance to these drugs may be related to changes in membrane permeability.

Note:
ACKNOWLEDGMENTS The tumor lines were supplied initially by Mr. I. Wodinsky. The assistance of Dr. William De-Wys, Miss Regina Bruns, and Mrs. Marge Richter in the propagation and isolation of tumor cells is acknowledged. Mrs. Gerilyn Pike, Mr. Kenneth Case, and Mr. David Zogg assisted with the experimental determinations.

Submitted on February 4, 1970






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