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Molecular Pharmacology, Vol 6, 532-539, Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics

Biochemical Effects of Niridazole on Schistosoma mansoni

ERNEST BUEDING 1 and JEAN FISHER 1

1 Department of Pathobiology, School of Hygiene and Public Health, and Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Administration to the host of the nitrothiazole derivative niridazole, an antischistosomal drug, results in a reduction in the glycogen levels of male schistosomes. This effect precedes observable functional damage to the worm, e.g., a hepatic shift, and is accounted for by a reduced rate of the conversion of active schistosome glycogen phosphorylase to its inactive form. This niridazole-induced effect is not completely selective, because the rate of glycogen phosphorylase inactivation in the host's skeletal muscle is also decreased following administration of niridazole, although to a much lesser degree than in the parasite.

Submitted on May 25, 1970




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P. E. Hartman, K. Levine, Z. Hartman, and H. Berger
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Science, June 4, 1971; 172(3987): 1058 - 1060.
[Abstract] [PDF]


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