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Molecular Pharmacology, Vol 6, 567-572, Copyright © 1970 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition of Methanol and Ethanol Oxidation by Pyrazole in the Rat and Monkey in Vivo

W. D. WATKINS 1, J. I. GOODMAN 1, and T. R. TEPHLY 1

1 Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48104

Pyrazole has no effect on the catalase-peroxidative system but exerts a pronounced inhibition of liver alcohol dehydrogenase and ethanol oxidation in vivo. Methanol oxidation is decreased by pyrazole in the rat, where a role of liver alcohol dehydrogenase has not previously been established. However, the inhibitory effect of Pyrazole on methanol oxidation is more marked in the monkey, where alcohol dehydrogenase is the major catalyst for methanol oxidation.

Note:
ACKNOWLEDGMENT The authors gratefully acknowledge the technical assistance of Mrs. Fernande Tinelli in these studies.

Submitted on May 14, 1970






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