![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 60, Issue 1, 92-103, July 2001
Laboratory of Molecular Neurobiology, Centre for Addiction and
Mental Health, Toronto, Ontario, Canada; and Departments of
Pharmacology, Psychiatry, and Institute of Medical Science, University
of Toronto
The ability of dopamine D4 and D2 receptors to
activate extracellular signal-regulated kinases (ERKs) 1 and 2 was
compared using Chinese hamster ovary (CHO-K1) cells transfected with
D4.2, D4.4, D4.7, and
D2L receptors. Dopamine stimulation of D4 or
D2L receptors produced a transient, dose-dependent increase
in ERK1/2 activity. Receptor-specific activation of the ERK
mitogen-activated protein kinase (MAPK) pathway was confirmed using the
D2-like receptor-selective agonist quinpirole, whereas the
specific antagonist haloperidol blocked activation. MAPK stimulation
was dependent on a pertussis-toxin-sensitive G protein
(Gi/o). trans-Activation of the
platelet-derived growth factor (PDGF) receptor was an essential step in
D4 and D2L receptor-induced MAPK activation.
PDGF receptor-selective tyrosine kinase inhibitors tyrphostin A9 and
AG1295 abolished or significantly inhibited ERK1/2 activation by
D4 and D2L receptors. Dopamine stimulation of
the D4 receptor also produced a rapid increase in tyrosine
phosphorylation of the PDGF receptor-
. The Src-family tyrosine
kinase inhibitor PP2 blocked MAPK activation by dopamine; however, this
drug was also found to inhibit PDGF-BB-stimulated ERK activity and
autophosphorylation of the PDGF receptor-. Downstream signaling
pathways support the involvement of a receptor tyrosine kinase. The
phosphoinositide 3-kinase inhibitors wortmannin and LY294002, protein
kinase C inhibitors GF109203X and Calphostin C, dominant-negative
RasN17, and the MEK inhibitor PD98059 significantly attenuated or
abolished activation of MAPK by dopamine D4 and D2L receptors. Our results indicate that D4 and
D2L receptors activate the ERK kinase cascade by first
mobilizing signaling by the PDGF receptor, followed by the subsequent
activation of ERK1/2 by pathways associated with this receptor tyrosine kinase.
This article has been cited by other articles:
|
|
 |
|
  E. T. van der Westhuizen, T. D. Werry, P. M. Sexton, and R. J. Summers The Relaxin Family Peptide Receptor 3 Activates Extracellular Signal-Regulated Kinase 1/2 through a Protein Kinase C-Dependent Mechanism Mol. Pharmacol., June 1, 2007; 71(6): 1618 - 1629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Mojsilovic-Petrovic, G.-B. Jeong, A. Crocker, A. Arneja, S. David, D. Russell, and R. G. Kalb Protecting Motor Neurons from Toxic Insult by Antagonism of Adenosine A2a and Trk Receptors J. Neurosci., September 6, 2006; 26(36): 9250 - 9263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-H. Wu, R. Goswami, L. K. Kim, W. E. Miller, K. Peppel, and N. J. Freedman The Platelet-derived Growth Factor Receptor-{beta} Phosphorylates and Activates G Protein-coupled Receptor Kinase-2: A MECHANISM FOR FEEDBACK INHIBITION J. Biol. Chem., September 2, 2005; 280(35): 31027 - 31035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Van Craenenbroeck, S. D. Clark, M. J. Cox, J. N. Oak, F. Liu, and H. H. M. Van Tol Folding Efficiency Is Rate-limiting in Dopamine D4 Receptor Biogenesis J. Biol. Chem., May 13, 2005; 280(19): 19350 - 19357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Trantham-Davidson, L. C. Neely, A. Lavin, and J. K. Seamans Mechanisms Underlying Differential D1 versus D2 Dopamine Receptor Regulation of Inhibition in Prefrontal Cortex J. Neurosci., November 24, 2004; 24(47): 10652 - 10659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Beom, D. Cheong, G. Torres, M. G. Caron, and K.-M. Kim Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal-regulated Kinase J. Biol. Chem., July 2, 2004; 279(27): 28304 - 28314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Millan, D. Cussac, A. Gobert, F. Lejeune, J.-M. Rivet, C. M. La Cour, A. Newman-Tancredi, and J.-L. Peglion S32504, a Novel Naphtoxazine Agonist at Dopamine D3/D2 Receptors: I. Cellular, Electrophysiological, and Neurochemical Profile in Comparison with Ropinirole J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 903 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Kim, M. Y. Kim, E. J. Lee, Y. S. Ahn, and J.-H. Baik Distinct Regulation of Internalization and Mitogen-Activated Protein Kinase Activation by Two Isoforms of the Dopamine D2 Receptor Mol. Endocrinol., March 1, 2004; 18(3): 640 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Maruyama, Y. Yamamoto, A. Shimizu, H. Masuda, N. Sakai, R. Sakurai, H. Asada, and Y. Yoshimura Pyrazolo Pyrimidine-Type Inhibitors of Src Family Tyrosine Kinases Promote Ovarian Steroid-Induced Differentiation of Human Endometrial Stromal Cells In Vitro Biol Reprod, January 1, 2004; 70(1): 214 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Davis, J. Ronesi, and D. M. Lovinger A Predominant Role for Inhibition of the Adenylate Cyclase/Protein Kinase A Pathway in ERK Activation by Cannabinoid Receptor 1 in N1E-115 Neuroblastoma Cells J. Biol. Chem., December 5, 2003; 278(49): 48973 - 48980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Stonehouse, M. Adachi, E. C. Walcott, and F. S. Jones Caffeine Regulates Neuronal Expression of the Dopamine 2 Receptor Gene Mol. Pharmacol., December 1, 2003; 64(6): 1463 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. D. Nair and S. C. Sealfon Agonist-specific Transactivation of Phosphoinositide 3-Kinase Signaling Pathway Mediated by the Dopamine D2 Receptor J. Biol. Chem., November 21, 2003; 278(47): 47053 - 47061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yang, H. Zhang, T. Voyno-Yasenetskaya, and R. D. Ye Requirement of G{beta}{gamma} and c-Src in D2 Dopamine Receptor-Mediated Nuclear Factor-{kappa}B Activation Mol. Pharmacol., August 1, 2003; 64(2): 447 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.A. Lemon, D.R. Boreham, and C.D. Rollo A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes Experimental Biology and Medicine, July 1, 2003; 228(7): 800 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Y.-P. Ko, M. L. Ko, and S. E. Dryer Circadian Phase-Dependent Modulation of cGMP-Gated Channels of Cone Photoreceptors by Dopamine and D2 Agonist J. Neurosci., April 15, 2003; 23(8): 3145 - 3153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liu, M. H. Ghahremani, B. Banihashemi, and P. R. Albert Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gbeta gamma -subunits in Balb/c-3T3 cells Am J Physiol Cell Physiol, March 1, 2003; 284(3): C640 - C648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Belcheva, P. D. Haas, Y. Tan, V. M. Heaton, and C. J. Coscia The Fibroblast Growth Factor Receptor Is at the Site of Convergence between {micro}-Opioid Receptor and Growth Factor Signaling Pathways in Rat C6 Glioma Cells J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 909 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lavine, N. Ethier, J. N. Oak, L. Pei, F. Liu, P. Trieu, R. V. Rebois, M. Bouvier, T. E. Hebert, and H. H. M. Van Tol G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase J. Biol. Chem., November 22, 2002; 277(48): 46010 - 46019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mochizuki, B. Brassart, and A. Hinek Signaling Pathways Transduced through the Elastin Receptor Facilitate Proliferation of Arterial Smooth Muscle Cells J. Biol. Chem., November 15, 2002; 277(47): 44854 - 44863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Iaccarino, T. A. Samad, C. Mathis, H. Kercret, R. Picetti, and E. Borrelli Control of lactotrop proliferation by dopamine: Essential role of signaling through D2 receptors and ERKs PNAS, October 29, 2002; 99(22): 14530 - 14535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Liu, R. E. Baker, C. Sun, V. C. Sundmark, and H. P. Elsholtz Activation of Go-coupled Dopamine D2 Receptors Inhibits ERK1/ERK2 in Pituitary Cells. A KEY STEP IN THE TRANSCRIPTIONAL SUPPRESSION OF THE PROLACTIN GENE J. Biol. Chem., September 20, 2002; 277(39): 35819 - 35825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Endo, K.-I. Nagashima, H. Kurose, S. Mochizuki, M. Matsuda, and N. Mochizuki Sphingosine 1-Phosphate Induces Membrane Ruffling and Increases Motility of Human Umbilical Vein Endothelial Cells via Vascular Endothelial Growth Factor Receptor and CrkII J. Biol. Chem., June 21, 2002; 277(26): 23747 - 23754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Derkinderen, M. Toutant, G. Kadare, C. Ledent, M. Parmentier, and J.-A. Girault Dual Role of Fyn in the Regulation of FAK+6,7 by Cannabinoids in Hippocampus J. Biol. Chem., October 5, 2001; 276(41): 38289 - 38296. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
