![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 61, Issue 1, 1-6, January 2002
Pharmacogenetics Section, Laboratory of Reproductive and
Developmental Toxicology (A.U., Y.Y., T.S., M.N.) and National
Institute of Environmental Health Sciences (NIEHS) Microarray Center
(H.K.H., C.A.A.); Laboratory of Molecular Carcinogenesis, NIEHS,
National Institutes of Health, Research Triangle Park, North Carolina;
and Tularik, South San Francisco, California (H.K.W.,
J.M.L.)
Phenobarbital (PB) induces various gene encoding
drug/steroid-metabolizing enzymes such as cytochromes P450 (P450s)
and transferases. Although the nuclear orphan constitutive
active receptor (CAR) has been identified as a key transcription factor
that regulates the induction of CYP2B, the full scope of CAR-regulated
genes still remains a major question. To this end, reverse
transcriptase-polymerase chain reaction and cDNA microarray
techniques were employed to examine gene expression in wild-type and
CAR-null mice. The results show that a total of 138 genes were detected
to be either induced or repressed in response to PB treatment, of which
about half were under CAR regulation. Including CYP2B10, CYP3A11,
and NADPH-CYP reductase, CAR regulated a group of the PB-induced
drug/steroid-metabolizing enzymes. Enzymes such as amino
levulinate synthase 1 and squalene epoxidase displayed CAR-independent
induction by PB. Cyp4a10 and Cyp4a14
represented the group of genes induced by PB only in CAR-null mice,
indicating that CAR may be a transcription blocker that prevents these
genes from being induced by PB. Additionally, the group of genes
encoding enzymes and proteins involved in basic biological processes
such as energy metabolism underwent the CAR-dependent repression by PB.
Thus, CAR seems to have diverse roles, both as a positive and negative
regulator, in the regulation of hepatic genes in response to PB beyond
drug/steroid metabolism.
This article has been cited by other articles:
|
|
 |
|
  J. Gao, J. He, Y. Zhai, T. Wada, and W. Xie The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity J. Biol. Chem., September 18, 2009; 284(38): 25984 - 25992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yanagiba, Y. Ito, M. Kamijima, F. J. Gonzalez, and T. Nakajima Octachlorostyrene Induces Cytochrome P450, UDP-glucuronosyltransferase, and Sulfotransferase via the Aryl Hydrocarbon Receptor and Constitutive Androstane Receptor Toxicol. Sci., September 1, 2009; 111(1): 19 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Phillips, L. D. Burgoon, and J. I. Goodman The Constitutive Active/Androstane Receptor Facilitates Unique Phenobarbital-Induced Expression Changes of Genes Involved in Key Pathways in Precancerous Liver and Liver Tumors Toxicol. Sci., August 1, 2009; 110(2): 319 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Xu, X. Wang, and J. L. Staudinger Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor Drug Metab. Dispos., July 1, 2009; 37(7): 1539 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chu, H. J. Einolf, R. Evers, G. Kumar, D. Moore, S. Ripp, J. Silva, V. Sinha, M. Sinz, and A. Skerjanec In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective Drug Metab. Dispos., July 1, 2009; 37(7): 1339 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nesnow, W. Ward, T. Moore, H. Ren, and S. D. Hester Discrimination of Tumorigenic Triazole Conazoles from Phenobarbital by Transcriptional Analyses of Mouse Liver Gene Expression Toxicol. Sci., July 1, 2009; 110(1): 68 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Phillips, L. D. Burgoon, and J. I. Goodman Phenobarbital Elicits Unique, Early Changes in the Expression of Hepatic Genes that Affect Critical Pathways in Tumor-Prone B6C3F1 Mice Toxicol. Sci., June 1, 2009; 109(2): 193 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Beilke, L. M. Aleksunes, R. D. Holland, D. G. Besselsen, R. D. Beger, C. D. Klaassen, and N. J. Cherrington Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice Drug Metab. Dispos., May 1, 2009; 37(5): 1035 - 1045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, T. Chen, J. Cottrell, and H. Wang Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes Drug Metab. Dispos., May 1, 2009; 37(5): 1098 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Alnouti Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification Toxicol. Sci., April 1, 2009; 108(2): 225 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Phillips and J. I. Goodman Multiple Genes Exhibit Phenobarbital-Induced Constitutive Active/Androstane Receptor-Mediated DNA Methylation Changes during Liver Tumorigenesis and in Liver Tumors Toxicol. Sci., April 1, 2009; 108(2): 273 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Deguchi, T. Yamada, Y. Hirose, H. Nagahori, M. Kushida, K. Sumida, T. Sukata, Y. Tomigahara, K. Nishioka, S. Uwagawa, et al. Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation Toxicol. Sci., March 1, 2009; 108(1): 69 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamada, S. Uwagawa, Y. Okuno, S. M. Cohen, and H. Kaneko Case Study: An Evaluation of the Human Relevance of the Synthetic Pyrethroid Metofluthrin-Induced Liver Tumors in Rats Based on Mode of Action Toxicol. Sci., March 1, 2009; 108(1): 59 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Dail, L. A. Shack, J. E. Chambers, and S. C. Burgess Global Liver Proteomics of Rats Exposed for 5 Days to Phenobarbital Identifies Changes Associated with Cancer and with CYP Metabolism Toxicol. Sci., December 1, 2008; 106(2): 556 - 569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng and C. D. Klaassen Perfluorocarboxylic Acids Induce Cytochrome P450 Enzymes in Mouse Liver through Activation of PPAR-{alpha} and CAR Transcription Factors Toxicol. Sci., November 1, 2008; 106(1): 29 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Cheng and C. D. Klaassen Critical Role of PPAR-{alpha} in Perfluorooctanoic Acid- and Perfluorodecanoic Acid-Induced Downregulation of Oatp Uptake Transporters in Mouse Livers Toxicol. Sci., November 1, 2008; 106(1): 37 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Masson, M. Qatanani, A. L. Sberna, R. Xiao, J. P. Pais de Barros, J. Grober, V. Deckert, A. Athias, P. Gambert, L. Lagrost, et al. Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice J. Lipid Res., August 1, 2008; 49(8): 1682 - 1691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Membrez, F. Blancher, M. Jaquet, R. Bibiloni, P. D. Cani, R. G. Burcelin, I. Corthesy, K. Mace, and C. J. Chou Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice FASEB J, July 1, 2008; 22(7): 2416 - 2426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Rosen, B. D. Abbott, D. C. Wolf, J. C. Corton, C. R. Wood, J. E. Schmid, K. P. Das, R. D. Zehr, E. T. Blair, and C. Lau Gene Profiling in the Livers of Wild-type and PPAR{alpha}-Null Mice Exposed to Perfluorooctanoic Acid Toxicol Pathol, June 1, 2008; 36(4): 592 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Sueyoshi, R. Moore, J. Sugatani, Y. Matsumura, and M. Negishi PPP1R16A, The Membrane Subunit of Protein Phosphatase 1{beta}, Signals Nuclear Translocation of the Nuclear Receptor Constitutive Active/Androstane Receptor Mol. Pharmacol., April 1, 2008; 73(4): 1113 - 1121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. D. Beilke, D. G. Besselsen, Q. Cheng, S. Kulkarni, A. L. Slitt, and N. J. Cherrington Minimal Role of Hepatic Transporters in the Hepatoprotection against LCA-Induced Intrahepatic Cholestasis Toxicol. Sci., March 1, 2008; 102(1): 196 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Alnouti and C. D. Klaassen Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 612 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Hernandez, W. Huang, L. M. Chapman, S. Chua, D. D. Moore, and W. S. Baldwin The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor Toxicol. Sci., August 1, 2007; 98(2): 416 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Woods, J. P. Vanden Heuvel, and I. Rusyn Genomic Profiling in Nuclear Receptor-Mediated Toxicity Toxicol Pathol, June 1, 2007; 35(4): 474 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamazaki, S. Kakizaki, N. Horiguchi, N. Sohara, K. Sato, H. Takagi, M. Mori, and M. Negishi The role of the nuclear receptor constitutive androstane receptor in the pathogenesis of non-alcoholic steatohepatitis Gut, April 1, 2007; 56(4): 565 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakamura, R. Moore, M. Negishi, and T. Sueyoshi Nuclear Pregnane X Receptor Cross-talk with FoxA2 to Mediate Drug-induced Regulation of Lipid Metabolism in Fasting Mouse Liver J. Biol. Chem., March 30, 2007; 282(13): 9768 - 9776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Auerbach, J. G. DeKeyser, M. A. Stoner, and C. J. Omiecinski CAR2 Displays Unique Ligand Binding and RXR{alpha} Heterodimerization Characteristics Drug Metab. Dispos., March 1, 2007; 35(3): 428 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Phillips, Y. Yamamoto, M. Negishi, R. R. Maronpot, and J. I. Goodman Orphan Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Alterations in DNA Methylation during Phenobarbital Promotion of Liver Tumorigenesis Toxicol. Sci., March 1, 2007; 96(1): 72 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Blattler, F. Rencurel, M. R. Kaufmann, and U. A. Meyer In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase PNAS, January 16, 2007; 104(3): 1045 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Faucette, T.-C. Zhang, R. Moore, T. Sueyoshi, C. J. Omiecinski, E. L. LeCluyse, M. Negishi, and H. Wang Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 72 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Tien, K. Matsui, R. Moore, and M. Negishi The Nuclear Receptor Constitutively Active/Androstane Receptor Regulates Type 1 Deiodinase and Thyroid Hormone Activity in the Regenerating Mouse Liver J. Pharmacol. Exp. Ther., January 1, 2007; 320(1): 307 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Jackson, S. S. Ferguson, M. Negishi, and J. A. Goldstein Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor Drug Metab. Dispos., December 1, 2006; 34(12): 2003 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Nelson, V. Bhaskaran, W. R. Foster, and L. D. Lehman-McKeeman p53-Independent Induction of Rat Hepatic Mdm2 following Administration of Phenobarbital and Pregnenolone 16{alpha}-Carbonitrile Toxicol. Sci., December 1, 2006; 94(2): 272 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sakai, H. Iwata, E.-Y. Kim, O. Tsydenova, N. Miyazaki, E. A. Petrov, V. B. Batoev, and S. Tanabe Constitutive Androstane Receptor (CAR) as a Potential Sensing Biomarker of Persistent Organic Pollutants (POPs) in Aquatic Mammal: Molecular Characterization, Expression Level, and Ligand Profiling in Baikal Seal (Pusa sibirica) Toxicol. Sci., November 1, 2006; 94(1): 57 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Meijerman, J. H. Beijnen, and J. H.M. Schellens Herb-Drug Interactions in Oncology: Focus on Mechanisms of Induction Oncologist, July 1, 2006; 11(7): 742 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamamoto, R. Moore, H. A. Hess, G. L. Guo, F. J. Gonzalez, K. S. Korach, R. R. Maronpot, and M. Negishi Estrogen Receptor {alpha} Mediates 17{alpha}-Ethynylestradiol Causing Hepatotoxicity J. Biol. Chem., June 16, 2006; 281(24): 16625 - 16631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Faucette, T. Sueyoshi, C. M. Smith, M. Negishi, E. L. LeCluyse, and H. Wang Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1200 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Miao, S. Fang, Y. Bae, and J. K. Kemper Functional Inhibitory Cross-talk between Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 in Hepatic Lipid/Glucose Metabolism Is Mediated by Competition for Binding to the DR1 Motif and to the Common Coactivators, GRIP-1 and PGC-1{alpha} J. Biol. Chem., May 26, 2006; 281(21): 14537 - 14546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hosseinpour, R. Moore, M. Negishi, and T. Sueyoshi Serine 202 Regulates the Nuclear Translocation of Constitutive Active/Androstane Receptor Mol. Pharmacol., April 1, 2006; 69(4): 1095 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gong, S. V. Singh, S. P. Singh, Y. Mu, J. H. Lee, S. P. S. Saini, D. Toma, S. Ren, V. E. Kagan, B. W. Day, et al. Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells Mol. Endocrinol., February 1, 2006; 20(2): 279 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Holsapple, H. C. Pitot, S. H. Cohen, A. R. Boobis, J. E. Klaunig, T. Pastoor, V. L. Dellarco, and Y. P. Dragan Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk Toxicol. Sci., January 1, 2006; 89(1): 51 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Corton and H. M. Brown-Borg Peroxisome Proliferator-Activated Receptor {gamma} Coactivator 1 in Caloric Restriction and Other Models of Longevity J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2005; 60(12): 1494 - 1509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Auerbach, M. A. Stoner, S. Su, and C. J. Omiecinski Retinoid X Receptor-{alpha}-Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3) Mol. Pharmacol., November 1, 2005; 68(5): 1239 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gnerre, G. U. Schuster, A. Roth, C. Handschin, L. Johansson, R. Looser, P. Parini, M. Podvinec, K. Robertsson, J.-A. Gustafsson, et al. LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver J. Lipid Res., August 1, 2005; 46(8): 1633 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mu, C. R. J. Stephenson, C. Kendall, S. P. S. Saini, D. Toma, S. Ren, H. Cai, S. C. Strom, B. W. Day, P. Wipf, et al. A Pregnane X Receptor Agonist with Unique Species-Dependent Stereoselectivity and Its Implications in Drug Development Mol. Pharmacol., August 1, 2005; 68(2): 403 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding and J. L. Staudinger The Ratio of Constitutive Androstane Receptor to Pregnane X Receptor Determines the Activity of Guggulsterone against the Cyp2b10 Promoter J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 120 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Desaulniers, G. M. Cooke, K. Leingartner, K. Soumano, J. Cole, J. Yang, M. Wade, and A. Yagminas Effects of Postnatal Exposure to a Mixture of Polychlorinated Biphenyls, p,p'-dichlorodiphenyltrichloroethane, and p-p'-dichlorodiphenyldichloroethene in Prepubertal and Adult Female Sprague-Dawley Rats International Journal of Toxicology, March 1, 2005; 24(2): 111 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ekins, E. Kirillov, E. A. Rakhmatulin, and T. Nikolskaya A NOVEL METHOD FOR VISUALIZING NUCLEAR HORMONE RECEPTOR NETWORKS RELEVANT TO DRUG METABOLISM Drug Metab. Dispos., March 1, 2005; 33(3): 474 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jyrkkarinne, B. Windshugel, J. Makinen, M. Ylisirnio, M. Perakyla, A. Poso, W. Sippl, and P. Honkakoski Amino Acids Important for Ligand Specificity of the Human Constitutive Androstane Receptor J. Biol. Chem., February 18, 2005; 280(7): 5960 - 5971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Swales, S. Kakizaki, Y. Yamamoto, K. Inoue, K. Kobayashi, and M. Negishi Novel CAR-mediated Mechanism for Synergistic Activation of Two Distinct Elements within the Human Cytochrome P450 2B6 Gene in HepG2 Cells J. Biol. Chem., February 4, 2005; 280(5): 3458 - 3466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yamamoto, R. Moore, T. L. Goldsworthy, M. Negishi, and R. R. Maronpot The Orphan Nuclear Receptor Constitutive Active/Androstane Receptor Is Essential for Liver Tumor Promotion by Phenobarbital in Mice Cancer Res., October 15, 2004; 64(20): 7197 - 7200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kodama, C. Koike, M. Negishi, and Y. Yamamoto Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes Mol. Cell. Biol., September 15, 2004; 24(18): 7931 - 7940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, S. Faucette, R. Moore, T. Sueyoshi, M. Negishi, and E. LeCluyse Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin J. Biol. Chem., July 9, 2004; 279(28): 29295 - 29301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Swales and M. Negishi CAR, Driving into the Future Mol. Endocrinol., July 1, 2004; 18(7): 1589 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Podvinec, C. Handschin, R. Looser, and U. A. Meyer Identification of the xenosensors regulating human 5-aminolevulinate synthase PNAS, June 15, 2004; 101(24): 9127 - 9132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Jackson, S. S. Ferguson, R. Moore, M. Negishi, and J. A. Goldstein The Constitutive Active/Androstane Receptor Regulates Phenytoin Induction of Cyp2c29 Mol. Pharmacol., June 1, 2004; 65(6): 1397 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maglich, J. Watson, P. J. McMillen, B. Goodwin, T. M. Willson, and J. T. Moore The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction J. Biol. Chem., May 7, 2004; 279(19): 19832 - 19838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. S. Saini, J. Sonoda, L. Xu, D. Toma, H. Uppal, Y. Mu, S. Ren, D. D. Moore, R. M. Evans, and W. Xie A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification Mol. Pharmacol., February 1, 2004; 65(2): 292 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsumura, T. Saito, Y. Takahashi, T. Ozeki, K. Kiyotani, M. Fujieda, H. Yamazaki, H. Kunitoh, and T. Kamataki Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene Mol. Pharmacol., February 1, 2004; 65(2): 326 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Shenoy, T. A. Spencer, N. A. Mercer-Haines, M. Alipour, M. D. Gargano, M. Runge-Morris, and T. A. Kocarek CYP3A INDUCTION BY LIVER X RECEPTOR LIGANDS IN PRIMARY CULTURED RAT AND MOUSE HEPATOCYTES IS MEDIATED BY THE PREGNANE X RECEPTOR Drug Metab. Dispos., January 1, 2004; 32(1): 66 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bauer, N. Wolfram, G. F. Kahl, and K. I. Hirsch-Ernst Transcriptional Regulation of CYP2B1 Induction in Primary Rat Hepatocyte Cultures: Repression by Epidermal Growth Factor Is Mediated via a Distal Enhancer Region Mol. Pharmacol., January 1, 2004; 65(1): 172 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Handschin and U. A. Meyer Induction of Drug Metabolism: The Role of Nuclear Receptors Pharmacol. Rev., December 1, 2003; 55(4): 649 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kobayashi, T. Sueyoshi, K. Inoue, R. Moore, and M. Negishi Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells Mol. Pharmacol., November 1, 2003; 64(5): 1069 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Fraser, A. Zumsteg, and U. A. Meyer Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Activate a Drug-responsive Enhancer of the Murine 5-Aminolevulinic Acid Synthase Gene J. Biol. Chem., October 10, 2003; 278(41): 39392 - 39401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Desaulniers, K. Leingartner, B. Musicki, A. Yagminas, G.-H. Xiao, J. Cole, L. Marro, M. Charbonneau, and B. K. Tsang Effects of Postnatal Exposure to Mixtures of Non-ortho-PCBs, PCDDs, and PCDFs in Prepubertal Female Rats Toxicol. Sci., October 1, 2003; 75(2): 468 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chen, S. S. Ferguson, M. Negishi, and J. A. Goldstein Identification of Constitutive Androstane Receptor and Glucocorticoid Receptor Binding Sites in the CYP2C19 Promoter Mol. Pharmacol., August 1, 2003; 64(2): 316 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kinoshita, H. Wanibuchi, K. Morimura, M. Wei, J. Shen, S. Imaoka, Y. Funae, and S. Fukushima Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression Carcinogenesis, August 1, 2003; 24(8): 1389 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Gu, Y. Weng, Q.-Y. Zhang, H. Cui, M. Behr, L. Wu, W. Yang, L. Zhang, and X. Ding Liver-specific Deletion of the NADPH-Cytochrome P450 Reductase Gene: IMPACT ON PLASMA CHOLESTEROL HOMEOSTASIS AND THE FUNCTION AND REGULATION OF MICROSOMAL CYTOCHROME P450 AND HEME OXYGENASE J. Biol. Chem., July 3, 2003; 278(28): 25895 - 25901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rosenfeld, R. Vargas Jr., W. Xie, and R. M. Evans Genetic Profiling Defines the Xenobiotic Gene Network Controlled by the Nuclear Receptor Pregnane X Receptor Mol. Endocrinol., July 1, 2003; 17(7): 1268 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Auerbach, R. Ramsden, M. A. Stoner, C. Verlinde, C. Hassett, and C. J. Omiecinski Alternatively spliced isoforms of the human constitutive androstane receptor Nucleic Acids Res., June 15, 2003; 31(12): 3194 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-W. Kim, K. Park, E. Kwak, E. Choi, S. Lee, J. Ham, H. Kang, J. M. Kim, S. Y. Hwang, Y.-Y. Kong, et al. Activating Signal Cointegrator 2 Required for Liver Lipid Metabolism Mediated by Liver X Receptors in Mice Mol. Cell. Biol., May 15, 2003; 23(10): 3583 - 3592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maglich, D. J. Parks, L. B. Moore, J. L. Collins, B. Goodwin, A. N. Billin, C. A. Stoltz, S. A. Kliewer, M. H. Lambert, T. M. Willson, et al. Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes J. Biol. Chem., May 2, 2003; 278(19): 17277 - 17283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, S. R. Faucette, D. Gilbert, S. L. Jolley, T. Sueyoshi, M. Negishi, and E. L. LeCluyse Glucocorticoid Receptor Enhancement of Pregnane X Receptor-Mediated CYP2B6 Regulation in Primary Human Hepatocytes Drug Metab. Dispos., May 1, 2003; 31(5): 620 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Daniel and I. Rubio-Aliaga An update on renal peptide transporters Am J Physiol Renal Physiol, May 1, 2003; 284(5): F885 - F892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. A. Wooltorton, V. I. Pidoplichko, R. S. Broide, and J. A. Dani Differential Desensitization and Distribution of Nicotinic Acetylcholine Receptor Subtypes in Midbrain Dopamine Areas J. Neurosci., April 15, 2003; 23(8): 3176 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Wang, S. Faucette, T. Sueyoshi, R. Moore, S. Ferguson, M. Negishi, and E. L. LeCluyse A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression J. Biol. Chem., April 11, 2003; 278(16): 14146 - 14152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shiraki, N. Sakai, E. Kanaya, and H. Jingami Activation of Orphan Nuclear Constitutive Androstane Receptor Requires Subnuclear Targeting by Peroxisome Proliferator-activated Receptor gamma Coactivator-1alpha . A POSSIBLE LINK BETWEEN XENOBIOTIC RESPONSE AND NUTRITIONAL STATE J. Biol. Chem., March 21, 2003; 278(13): 11344 - 11350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Pascussi, M. Busson-Le Coniat, P. Maurel, and M.-J. Vilarem Transcriptional Analysis of the Orphan Nuclear Receptor Constitutive Androstane Receptor (NR1I3) Gene Promoter: Identification of a Distal Glucocorticoid Response Element Mol. Endocrinol., January 1, 2003; 17(1): 42 - 55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Dogra, D. Tremethick, and B. K. May Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene Mol. Pharmacol., January 1, 2003; 63(1): 73 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Cartee, S. C. Maggio, R. Smith, H. M. Sankala, P. Dent, and S. Grant Protein Kinase C-dependent Activation of the Tumor Necrosis Factor Receptor-mediated Extrinsic Cell Death Pathway Underlies Enhanced Apoptosis in Human Myeloid Leukemia Cells Exposed to Bryostatin 1 and Flavopiridol Mol. Cancer Ther., January 1, 2003; 2(1): 83 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Stulnig, K. R. Steffensen, H. Gao, M. Reimers, K. Dahlman-Wright, G. U. Schuster, and J.-A. Gustafsson Novel Roles of Liver X Receptors Exposed by Gene Expression Profiling in Liver and Adipose Tissue Mol. Pharmacol., December 1, 2002; 62(6): 1299 - 1305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Xiao, X. Cui, V. Madison, R. E. White, and K.-C. Cheng Insights from a Three-Dimensional Model into Ligand Binding to Constitutive Active Receptor Drug Metab. Dispos., September 1, 2002; 30(9): 951 - 956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maglich, C. M. Stoltz, B. Goodwin, D. Hawkins-Brown, J. T. Moore, and S. A. Kliewer Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification Mol. Pharmacol., September 1, 2002; 62(3): 638 - 646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Ferguson, E. L. LeCluyse, M. Negishi, and J. A. Goldstein Regulation of Human CYP2C9 by the Constitutive Androstane Receptor: Discovery of a New Distal Binding Site Mol. Pharmacol., September 1, 2002; 62(3): 737 - 746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Willson and J. T. Moore Minireview: Genomics Versus Orphan Nuclear Receptors--A Half-Time Report Mol. Endocrinol., June 1, 2002; 16(6): 1135 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ueda, S. Kakizaki, M. Negishi, and T. Sueyoshi Residue Threonine 350 Confers Steroid Hormone Responsiveness to the Mouse Nuclear Orphan Receptor CAR Mol. Pharmacol., June 1, 2002; 61(6): 1284 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Clyne, L.-F. Wang, and R. I. Hume Mutational Analysis of the Conserved Cysteines of the Rat P2X2 Purinoceptor J. Neurosci., May 15, 2002; 22(10): 3873 - 3880. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
