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Vol. 61, Issue 2, 255-259, February 2002
Department of Pathology and Laboratory Medicine, Jonsson
Comprehensive Cancer Center, and Molecular Biology Institute,
UCLA, Los Angeles, California
Representational difference analysis was used to isolate cDNAs
corresponding to 2,3,7,8-tetrachlorodibenzo-p-dioxin
(dioxin)-inducible genes from mouse Hepa-1 cells. One cDNA encoded a
novel cytochrome P450. The human homolog was also isolated and
later proved to be human CYP2S1. The induction of mouse CYP2S1 mRNA by
dioxin represents a primary response and required the aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins. The induction of CYP2S1 also occurred in mouse liver and lung, with the
highest expression found in lung. CYP2S1 was also inducible in a human
lung epithelial cell line. The dioxin-inducibility of CY2S1 is
exceptional, because all previously well-characterized cases of the
induction of cytochromes P450 by dioxin involve members of the CYP1 family.
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