MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lass, A.
Right arrow Articles by Brunner, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lass, A.
Right arrow Articles by Brunner, F.

Vol. 61, Issue 5, 1081-1088, May 2002

Functional and Analytical Evidence for Scavenging of Oxygen Radicals by L-Arginine

Achim Lass, Astrid Suessenbacher, Gerald Wölkart, Bernd Mayer, and Friedrich Brunner

Department of Pharmacology and Toxicology, Karl-Franzens-Universität Graz, Graz, Austria

L-Arginine, the substrate of nitric oxide synthase, is known to exert favorable effects in the prevention and treatment of cardiovascular diseases. In several conditions, including atherosclerosis and ischemia/reperfusion, where oxygen metabolites are thought to mediate endothelial and myocardial injury, L-arginine has protective effects. Here we studied the mechanisms by which L-arginine protects against oxygen radical-induced myocardial injury. Buffer-perfused rat hearts were subjected to oxygen radicals generated by electrolysis or to hypoxanthine and xanthine oxidase, which generates superoxide anions (O&cjs1138;2). Both sources of radicals impaired myocardial contractility, whereas L-arginine prevented the impairment. The observation that D-arginine as well as nitric oxide synthase inhibitors, such as NG-nitro-L-arginine but not glycine, had similar cardioprotective effects indicated that the protection might be due to a direct chemical interaction of L-arginine and its derivatives with oxygen radicals. In support, L-arginine and the derivatives prevented the formation of O&cjs1138;2 as determined by sensitive standard methods, whereas glycine did not. The radical scavenging activity of L-arginine and derivatives was dose-dependent, with an apparent rate constant of approximately 4.8 × 103 M s-1 for the reaction of L-arginine with O&cjs1138;2 as determined by electron paramagnetic resonance spectroscopy using 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine (TEMPONE-H) as spin trap. In summary, the results of this study demonstrate protective effects of L-arginine against oxygen radical-induced cardiac injury by free radical scavenging.

Copyright © 2002 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
K. J. Greenlee, Z. Werb, and F. Kheradmand
Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted
Physiol Rev, January 1, 2007; 87(1): 69 - 98.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
B. Pozo-Navas, H. Stessel, G. Wolkart, and F. Brunner
Role of Myocardial Nitric Oxide in Diabetic Ischemia-Reperfusion Dysfunction: Studies in Mice with Myocyte-Specific Overexpression of Endothelial Nitric-Oxide Synthase
J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 729 - 738.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. K. Chohan, R. B. Singh, N. S. Dhalla, and T. Netticadan
L-Arginine administration recovers sarcoplasmic reticulum function in ischemic reperfused hearts by preventing calpain activation
Cardiovasc Res, January 1, 2006; 69(1): 152 - 163.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
R. Saxena and P. K. Chakraborti
Identification of Regions Involved in Enzymatic Stability of Peptide Deformylase of Mycobacterium tuberculosis
J. Bacteriol., December 1, 2005; 187(23): 8216 - 8220.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. C. Souza-Costa, T. Zerbini, A. C. Palei, R. F. Gerlach, and J. E. Tanus-Santos
L-arginine Attenuates Acute Pulmonary Embolism-Induced Increases in Lung Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9
Chest, November 1, 2005; 128(5): 3705 - 3710.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Palm, D. G. Buerk, P.-O. Carlsson, P. Hansell, and P. Liss
Reduced Nitric Oxide Concentration in the Renal Cortex of Streptozotocin-Induced Diabetic Rats: Effects on Renal Oxygenation and Microcirculation
Diabetes, November 1, 2005; 54(11): 3282 - 3287.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
R. Hernanz, M. J Alonso, H. Zibrandtsen, Y. Alvarez, M. Salaices, and U. Simonsen
Measurements of nitric oxide concentration and hyporeactivity in rat superior mesenteric artery exposed to endotoxin
Cardiovasc Res, April 1, 2004; 62(1): 202 - 211.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. H. Kown, M. A. Lijkwan, C. L. Jahncke, S. Murata, J. B. Rothbard, and R. C. Robbins
L-arginine polymers enhance coronary flow and reduce oxidative stress following cardiac transplantation in rats
J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 1065 - 1070.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2002 by the American Society for Pharmacology and Experimental Therapeutics