Inducible and Brain Region-Specific CREB Transgenic Mice

doi:10.1124/mol.61.6.1453

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):
Year:		Vol:		Page:

This Article

	Full Text
	Full Text (PDF)
	Submit a response
	Alert me when this article is cited
	Alert me when eLetters are posted
	Alert me if a correction is posted

Services

	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sakai, N.
	Articles by Duman, R. S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sakai, N.
	Articles by Duman, R. S.

Vol. 61, Issue 6, 1453-1464, June 2002

Inducible and Brain Region-Specific CREB Transgenic Mice

Norio Sakai, Johannes Thome, Samuel S. Newton, Jingshan Chen, Max B. Kelz, Cathy Steffen, Eric J. Nestler, and Ronald S. Duman

Division of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut (N.S., J.T., S.S.N., J.C., M.B.K., R.S.D.); and Department of Psychiatry, the University of Texas Southwestern Medical Center, Dallas, Texas (C.S., E.J.N.)

To investigate the role of cAMP response element-binding protein (CREB) in the adaptive responses to psychotropic drugs, wehave developed inducible, brain region-specific CREB transgenicmice using the tetracycline-regulated gene expression system.The tetracycline transactivator (tTA) was placed under the controlof 1.8-kilobase neuron-specific enolase (NSE) promoter for thispurpose. Different patterns of CREB overexpression were foundin striatum, nucleus accumbens, and cingulate cortex in differentlines of bitransgenic mice, and CREB expression was blocked byaddition of doxycycline, an analog of tetracycline. Overexpressionof CREB influenced the expression of other members of the CREB/ATFfamily of transcription factors, consistent with previous reports.In addition, psychostimulant induction of dynorphin, a neuropeptideregulated by drugs of abuse, was up-regulated in striatum. Finally,there was a significant reduction in cocaine-induced locomotoractivity in the CREB bitransgenic mice. These results are consistentwith a role for CREB in mediating adaptive changes that occurin response to drugs ofabuse.

This article has been cited by other articles:

J. A. DiNieri, C. L. Nemeth, A. Parsegian, T. Carle, V. V. Gurevich, E. Gurevich, R. L. Neve, E. J. Nestler, and W. A. Carlezon Jr
Altered Sensitivity to Rewarding and Aversive Drugs in Mice with Inducible Disruption of cAMP Response Element-Binding Protein Function within the Nucleus Accumbens
J. Neurosci., February 11, 2009; 29(6): 1855 - 1859.
[Abstract] [Full Text] [PDF]

D. A. Meyer, E. Richer, S. A. Benkovic, K. Hayashi, J. W. Kansy, C. F. Hale, L. Y. Moy, Y. Kim, J. P. O'Callaghan, L.-H. Tsai, et al.
Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology
PNAS, November 25, 2008; 105(47): 18561 - 18566.
[Abstract] [Full Text] [PDF]

N. Kojima, G. Borlikova, T. Sakamoto, K. Yamada, T. Ikeda, S. Itohara, H. Niki, and S. Endo
Inducible cAMP Early Repressor Acts as a Negative Regulator for Kindling Epileptogenesis and Long-Term Fear Memory
J. Neurosci., June 18, 2008; 28(25): 6459 - 6472.
[Abstract] [Full Text] [PDF]

T. A. Green, I. N. Alibhai, S. Unterberg, R. L. Neve, S. Ghose, C. A. Tamminga, and E. J. Nestler
Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior
J. Neurosci., February 27, 2008; 28(9): 2025 - 2032.
[Abstract] [Full Text] [PDF]

Y. H. Huang, Y. Lin, T. E. Brown, M.-H. Han, D. B. Saal, R. L. Neve, R. S. Zukin, B. A. Sorg, E. J. Nestler, R. C. Malenka, et al.
CREB Modulates the Functional Output of Nucleus Accumbens Neurons: A CRITICAL ROLE OF N-METHYL-D-ASPARTATE GLUTAMATE RECEPTOR (NMDAR) RECEPTORS
J. Biol. Chem., February 1, 2008; 283(5): 2751 - 2760.
[Abstract] [Full Text] [PDF]

J. McDaid, M. P. Graham, and T. C. Napier
Methamphetamine-Induced Sensitization Differentially Alters pCREB and {Delta}FosB throughout the Limbic Circuit of the Mammalian Brain
Mol. Pharmacol., December 1, 2006; 70(6): 2064 - 2074.
[Abstract] [Full Text] [PDF]

W. A. Kues, R. Schwinzer, D. Wirth, E. Verhoeyen, E. Lemme, D. Herrmann, B. Barg-Kues, H. Hauser, K. Wonigeit, and H. Niemann
Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs
FASEB J, June 1, 2006; 20(8): 1200 - 1202.
[Abstract] [Full Text] [PDF]

N. Sakai, H. Tsubokawa, M. Matsuzaki, T. Kajimoto, E. Takahashi, Y. Ren, S. Ohmori, Y. Shirai, H. Matsubayashi, J. Chen, et al.
Propagation of {gamma}PKC translocation along the dendrites of Purkinje cell in {gamma}PKC-GFP transgenic mice
Genes Cells, October 1, 2004; 9(10): 945 - 957.
[Abstract] [Full Text] [PDF]

S. S. Newton, J. Thome, T. L. Wallace, Y. Shirayama, L. Schlesinger, N. Sakai, J. Chen, R. Neve, E. J. Nestler, and R. S. Duman
Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect
J. Neurosci., December 15, 2002; 22(24): 10883 - 10890.
[Abstract] [Full Text] [PDF]

				D. A. Meyer, E. Richer, S. A. Benkovic, K. Hayashi, J. W. Kansy, C. F. Hale, L. Y. Moy, Y. Kim, J. P. O'Callaghan, L.-H. Tsai, et al. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology PNAS, November 25, 2008; 105(47): 18561 - 18566. [Abstract] [Full Text] [PDF]

				N. Kojima, G. Borlikova, T. Sakamoto, K. Yamada, T. Ikeda, S. Itohara, H. Niki, and S. Endo Inducible cAMP Early Repressor Acts as a Negative Regulator for Kindling Epileptogenesis and Long-Term Fear Memory J. Neurosci., June 18, 2008; 28(25): 6459 - 6472. [Abstract] [Full Text] [PDF]

				T. A. Green, I. N. Alibhai, S. Unterberg, R. L. Neve, S. Ghose, C. A. Tamminga, and E. J. Nestler Induction of Activating Transcription Factors (ATFs) ATF2, ATF3, and ATF4 in the Nucleus Accumbens and Their Regulation of Emotional Behavior J. Neurosci., February 27, 2008; 28(9): 2025 - 2032. [Abstract] [Full Text] [PDF]

				Y. H. Huang, Y. Lin, T. E. Brown, M.-H. Han, D. B. Saal, R. L. Neve, R. S. Zukin, B. A. Sorg, E. J. Nestler, R. C. Malenka, et al. CREB Modulates the Functional Output of Nucleus Accumbens Neurons: A CRITICAL ROLE OF N-METHYL-D-ASPARTATE GLUTAMATE RECEPTOR (NMDAR) RECEPTORS J. Biol. Chem., February 1, 2008; 283(5): 2751 - 2760. [Abstract] [Full Text] [PDF]

				J. McDaid, M. P. Graham, and T. C. Napier Methamphetamine-Induced Sensitization Differentially Alters pCREB and {Delta}FosB throughout the Limbic Circuit of the Mammalian Brain Mol. Pharmacol., December 1, 2006; 70(6): 2064 - 2074. [Abstract] [Full Text] [PDF]

				W. A. Kues, R. Schwinzer, D. Wirth, E. Verhoeyen, E. Lemme, D. Herrmann, B. Barg-Kues, H. Hauser, K. Wonigeit, and H. Niemann Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs FASEB J, June 1, 2006; 20(8): 1200 - 1202. [Abstract] [Full Text] [PDF]

				N. Sakai, H. Tsubokawa, M. Matsuzaki, T. Kajimoto, E. Takahashi, Y. Ren, S. Ohmori, Y. Shirai, H. Matsubayashi, J. Chen, et al. Propagation of {gamma}PKC translocation along the dendrites of Purkinje cell in {gamma}PKC-GFP transgenic mice Genes Cells, October 1, 2004; 9(10): 945 - 957. [Abstract] [Full Text] [PDF]

				S. S. Newton, J. Thome, T. L. Wallace, Y. Shirayama, L. Schlesinger, N. Sakai, J. Chen, R. Neve, E. J. Nestler, and R. S. Duman Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect J. Neurosci., December 15, 2002; 22(24): 10883 - 10890. [Abstract] [Full Text] [PDF]