![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 62, Issue 3, 485-496, September 2002
2
-4 Subunit
Johnson & Johnson Pharmaceutical Research and Development, Spring
House, Pennsylvania
The voltage-gated calcium channel is composed of a pore-forming
1 subunit and several regulatory subunits:
2
, 
, and 
. We report here the identification of
a novel 2 subunit, 2-4, from the
expressed sequence tag database followed by its cloning and
characterization. The novel 2-4 subunit gene contains
39 exons spanning about 130 kilobases and is co-localized with the CHCNA1C gene (1C subunit) on human chromosome
12p13.3. Alternative splicing of the 2-4 gene gives
rise to four potential variants, a through d. The open reading frame of
human 2-4a is composed of 3363 base pairs encoding a
protein with 1120 residues and a calculated molecular mass of
126 kDa. The 2-4a subunit shares 30, 32, and 61%
identity with the human calcium channel 2-1, 2-2, and 2-3 subunits,
respectively. Primary sequence comparison suggests that
2-4 lacks the gabapentin binding motifs characterized for 2-1 and 2-2; this was confirmed
by a [3H]gabapentin-binding assay. In human embryonic
kidney 293 cells, the 2-4 subunit associated with
CaV1.2 and 3 subunits and significantly increased CaV1.2/3-mediated Ca2+
influx. Immunohistochemical study revealed that the
2-4 subunit has limited distribution in special cell
types of the pituitary, adrenal gland, colon, and fetal liver. Whether
the 2-4 subunit plays a distinct physiological role
in select endocrine tissues remains to be demonstrated.
This article has been cited by other articles:
|
|
 |
|
  G. A. Fuller-Bicer, G. Varadi, S. E. Koch, M. Ishii, I. Bodi, N. Kadeer, J. N. Muth, G. Mikala, N. N. Petrashevskaya, M. A. Jordan, et al. Targeted disruption of the voltage-dependent calcium channel {alpha}2/{delta}-1-subunit Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H117 - H124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Dickman, P. T. Kurshan, and T. L. Schwarz Mutations in a Drosophila {alpha}2{delta} Voltage-Gated Calcium Channel Subunit Reveal a Crucial Synaptic Function J. Neurosci., January 2, 2008; 28(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Vela, M. I. Perez-Millan, D. Becu-Villalobos, and G. Diaz-Torga Different kinases regulate activation of voltage-dependent calcium channels by depolarization in GH3 cells Am J Physiol Cell Physiol, September 1, 2007; 293(3): C951 - C959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Reuben and A. Buvanendran Preventing the Development of Chronic Pain After Orthopaedic Surgery with Preventive Multimodal Analgesic Techniques J. Bone Joint Surg. Am., June 1, 2007; 89(6): 1343 - 1358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Herzig, I. F. Y. Khan, D. Grundemann, J. Matthes, A. Ludwig, G. Michels, U. C. Hoppe, D. Chaudhuri, A. Schwartz, D. T. Yue, et al. Mechanism of Cav1.2 channel modulation by the amino terminus of cardiac {beta}2-subunits FASEB J, May 1, 2007; 21(7): 1527 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Reuben, A. Buvanendran, J. S. Kroin, and K. Raghunathan The Analgesic Efficacy of Celecoxib, Pregabalin, and Their Combination for Spinal Fusion Surgery Anesth. Analg., November 1, 2006; 103(5): 1271 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-N. Yang and P.-O. Berggren The Role of Voltage-Gated Calcium Channels in Pancreatic {beta}-Cell Physiology and Pathophysiology Endocr. Rev., October 1, 2006; 27(6): 621 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Wycisk, B. Budde, S. Feil, S. Skosyrski, F. Buzzi, J. Neidhardt, E. Glaus, P. Nurnberg, K. Ruether, and W. Berger Structural and Functional Abnormalities of Retinal Ribbon Synapses due to Cacna2d4 Mutation. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3523 - 3530. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Strock and M. A. Diverse-Pierluissi Ca2+ Channels As Integrators of G Protein-Mediated Signaling in Neurons Mol. Pharmacol., November 1, 2004; 66(5): 1071 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Li, Y.-H. Song, E. S. Higuera, and Z. D. Luo Spinal Dorsal Horn Calcium Channel {alpha}2{delta}-1 Subunit Upregulation Contributes to Peripheral Nerve Injury-Induced Tactile Allodynia J. Neurosci., September 29, 2004; 24(39): 8494 - 8499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Dolphin G Protein Modulation of Voltage-Gated Calcium Channels Pharmacol. Rev., December 1, 2003; 55(4): 607 - 627. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
