![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 62, Issue 3, 638-646, September 2002
Nuclear Receptor Discovery Research (J.M.M., C.M.S., B.G., J.T.M.,
S.A.K.) and Bioscience Support (D.H.-B.), GlaxoSmithKline, Research
Triangle Park, North Carolina
The nuclear pregnane X receptor (PXR) and constitutive androstane
receptor (CAR) play central roles in protecting the body against
environmental chemicals (xenobiotics). PXR and CAR are activated by a
wide range of xenobiotics and regulate cytochrome P450 and other genes
whose products are involved in the detoxification of these chemicals.
In this report, we have used receptor-selective agonists together with
receptor-null mice to identify PXR and CAR target genes in the liver
and small intestine. Our results demonstrate that PXR and CAR regulate
overlapping but distinct sets of genes involved in all phases of
xenobiotic metabolism, including oxidative metabolism, conjugation, and
transport. Among the murine genes regulated by PXR were those encoding
PXR and CAR. We provide evidence that PXR regulates a similar program of genes involved in xenobiotic metabolism in human liver. Among the
genes regulated by PXR in primary human hepatocytes were the aryl
hydrocarbon receptor and its target genes CYP1A1 and
CYP1A2. These findings underscore the importance of
these two nuclear receptors in defending the body against a broad array
of potentially harmful xenobiotics.
This article has been cited by other articles:
|
|
 |
|
  C. Xu, X. Wang, and J. L. Staudinger Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor Drug Metab. Dispos., July 1, 2009; 37(7): 1539 - 1547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Chu, H. J. Einolf, R. Evers, G. Kumar, D. Moore, S. Ripp, J. Silva, V. Sinha, M. Sinz, and A. Skerjanec In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective Drug Metab. Dispos., July 1, 2009; 37(7): 1339 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nesnow, W. Ward, T. Moore, H. Ren, and S. D. Hester Discrimination of Tumorigenic Triazole Conazoles from Phenobarbital by Transcriptional Analyses of Mouse Liver Gene Expression Toxicol. Sci., July 1, 2009; 110(1): 68 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ott, G. Fricker, and B. Bauer Pregnane X Receptor (PXR) Regulates P-Glycoprotein at the Blood-Brain Barrier: Functional Similarities between Pig and Human PXR J. Pharmacol. Exp. Ther., April 1, 2009; 329(1): 141 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Lichti-Kaiser, C. Xu, and J. L. Staudinger Cyclic AMP-dependent Protein Kinase Signaling Modulates Pregnane x Receptor Activity in a Species-specific Manner J. Biol. Chem., March 13, 2009; 284(11): 6639 - 6649. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Hariparsad, X. Chu, J. Yabut, P. Labhart, D. P. Hartley, X. Dai, and R. Evers Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes Nucleic Acids Res., March 1, 2009; 37(4): 1160 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Szabo, V. M. Richardson, D. G. Ross, J. J. Diliberto, P. R. S. Kodavanti, and L. S. Birnbaum Effects of Perinatal PBDE Exposure on Hepatic Phase I, Phase II, Phase III, and Deiodinase 1 Gene Expression Involved in Thyroid Hormone Metabolism in Male Rat Pups Toxicol. Sci., January 1, 2009; 107(1): 27 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Lichti-Kaiser and J. L. Staudinger The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes Drug Metab. Dispos., August 1, 2008; 36(8): 1538 - 1545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Naspinski, X. Gu, G.-D. Zhou, S. U. Mertens-Talcott, K. C. Donnelly, and Y. Tian Pregnane X Receptor Protects HepG2 Cells from BaP-Induced DNA Damage Toxicol. Sci., July 1, 2008; 104(1): 67 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Rosen, B. D. Abbott, D. C. Wolf, J. C. Corton, C. R. Wood, J. E. Schmid, K. P. Das, R. D. Zehr, E. T. Blair, and C. Lau Gene Profiling in the Livers of Wild-type and PPAR{alpha}-Null Mice Exposed to Perfluorooctanoic Acid Toxicol Pathol, June 1, 2008; 36(4): 592 - 607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Sane, D. J. Buckley, A. R. Buckley, S. C. Nallani, and P. B. Desai Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells Drug Metab. Dispos., May 1, 2008; 36(5): 946 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Rosen, J. S. Lee, H. Ren, B. Vallanat, J. Liu, M. P. Waalkes, B. D. Abbott, C. Lau, and J. C. Corton Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPAR{alpha} and CAR Toxicol. Sci., May 1, 2008; 103(1): 46 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, H. Li, L. B. Moore, M. D. L. Johnson, J. M. Maglich, B. Goodwin, O. R. R. Ittoop, B. Wisely, K. Creech, D. J. Parks, et al. The Phytoestrogen Coumestrol Is a Naturally Occurring Antagonist of the Human Pregnane X Receptor Mol. Endocrinol., April 1, 2008; 22(4): 838 - 857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Silkworth, E. A. Carlson, C. McCulloch, K. Illouz, S. Goodwin, and T. R. Sutter Toxicogenomic Analysis of Gender, Chemical, and Dose Effects in Livers of TCDD- or Aroclor 1254-Exposed Rats Using a Multifactor Linear Model Toxicol. Sci., April 1, 2008; 102(2): 291 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Roth, R. Looser, M. Kaufmann, S. M. Blattler, F. Rencurel, W. Huang, D. D. Moore, and U. A. Meyer Regulatory Cross-Talk between Drug Metabolism and Lipid Homeostasis: Constitutive Androstane Receptor and Pregnane X Receptor Increase Insig-1 Expression Mol. Pharmacol., April 1, 2008; 73(4): 1282 - 1289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Callaghan, E. Crowley, S. Potter, and I. D. Kerr P-glycoprotein: So Many Ways to Turn It On J. Clin. Pharmacol., March 1, 2008; 48(3): 365 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Alnouti and C. D. Klaassen Regulation of Sulfotransferase Enzymes by Prototypical Microsomal Enzyme Inducers in Mice J. Pharmacol. Exp. Ther., February 1, 2008; 324(2): 612 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dixit, N. Hariparsad, F. Li, P. Desai, K. E. Thummel, and J. D. Unadkat Cytochrome P450 Enzymes and Transporters Induced by Anti-Human Immunodeficiency Virus Protease Inhibitors in Human Hepatocytes: Implications for Predicting Clinical Drug Interactions Drug Metab. Dispos., October 1, 2007; 35(10): 1853 - 1859. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wortham, M. Czerwinski, L. He, A. Parkinson, and Y.-J. Y. Wan Expression of Constitutive Androstane Receptor, Hepatic Nuclear Factor 4{alpha}, and P450 Oxidoreductase Genes Determines Interindividual Variability in Basal Expression and Activity of a Broad Scope of Xenobiotic Metabolism Genes in the Human Liver Drug Metab. Dispos., September 1, 2007; 35(9): 1700 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Dail, S. C. Burgess, E. C. Meek, J. Wagner, J. Baravik, and J. E. Chambers Spatial Distribution of CYP2B1/2 Messenger RNA within the Rat Liver Acinus following Exposure to the Inducers Phenobarbital and Dieldrin Toxicol. Sci., September 1, 2007; 99(1): 35 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Peffer, J. G. Moggs, T. Pastoor, R. A. Currie, J. Wright, G. Milburn, F. Waechter, and I. Rusyn Mouse Liver Effects of Cyproconazole, a Triazole Fungicide: Role of the Constitutive Androstane Receptor Toxicol. Sci., September 1, 2007; 99(1): 315 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Hernandez, W. Huang, L. M. Chapman, S. Chua, D. D. Moore, and W. S. Baldwin The Environmental Estrogen, Nonylphenol, Activates the Constitutive Androstane Receptor Toxicol. Sci., August 1, 2007; 98(2): 416 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Ricketts, M. V. Boekschoten, A. J. Kreeft, G. J. E. J. Hooiveld, C. J. A. Moen, M. Muller, R. R. Frants, S. Kasanmoentalib, S. M. Post, H. M. G. Princen, et al. The Cholesterol-Raising Factor from Coffee Beans, Cafestol, as an Agonist Ligand for the Farnesoid and Pregnane X Receptors Mol. Endocrinol., July 1, 2007; 21(7): 1603 - 1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Woods, J. P. Vanden Heuvel, and I. Rusyn Genomic Profiling in Nuclear Receptor-Mediated Toxicity Toxicol Pathol, June 1, 2007; 35(4): 474 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Auerbach, J. G. DeKeyser, M. A. Stoner, and C. J. Omiecinski CAR2 Displays Unique Ligand Binding and RXR{alpha} Heterodimerization Characteristics Drug Metab. Dispos., March 1, 2007; 35(3): 428 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kawase, Y. Tsunokuni, and M. Iwaki Effects of Alterations in CAR on Bilirubin Detoxification in Mouse Collagen-Induced Arthritis Drug Metab. Dispos., February 1, 2007; 35(2): 256 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G Traber Heart disease and single-vitamin supplementation Am. J. Clinical Nutrition, January 1, 2007; 85(1): 293S - 299S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang and B. Yan Photochemotherapeutic Agent 8-Methoxypsoralen Induces Cytochrome P450 3A4 and Carboxylesterase HCE2: Evidence on an Involvement of the Pregnane X Receptor Toxicol. Sci., January 1, 2007; 95(1): 13 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Allen, D. C. Wolf, M. H. George, S. D. Hester, G. Sun, S.-F. Thai, D. A. Delker, T. Moore, C. Jones, G. Nelson, et al. Toxicity Profiles in Mice Treated with Hepatotumorigenic and Non-Hepatotumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil Toxicol Pathol, December 1, 2006; 34(7): 853 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. O. Ward, D. A. Delker, S. D. Hester, S.-F. Thai, D. C. Wolf, J. W. Allen, and S. Nesnow Transcriptional Profiles in Liver from Mice Treated with Hepatotumorigenic and Nonhepatotumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil Toxicol Pathol, December 1, 2006; 34(7): 863 - 878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Hester, D. C. Wolf, S. Nesnow, and S.-F. Thai Transcriptional Profiles in Liver from Rats Treated with Tumorigenic and Non-tumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil Toxicol Pathol, December 1, 2006; 34(7): 879 - 894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Jackson, S. S. Ferguson, M. Negishi, and J. A. Goldstein Phenytoin Induction of the Cyp2c37 Gene Is Mediated by the Constitutive Androstane Receptor Drug Metab. Dispos., December 1, 2006; 34(12): 2003 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Guzelian, J. L. Barwick, L. Hunter, T. L. Phang, L. C. Quattrochi, and P. S. Guzelian Identification of Genes Controlled by the Pregnane X Receptor by Microarray Analysis of mRNAs from Pregnenolone 16{alpha}-Carbonitrile-Treated Rats Toxicol. Sci., December 1, 2006; 94(2): 379 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sakai, H. Iwata, E.-Y. Kim, O. Tsydenova, N. Miyazaki, E. A. Petrov, V. B. Batoev, and S. Tanabe Constitutive Androstane Receptor (CAR) as a Potential Sensing Biomarker of Persistent Organic Pollutants (POPs) in Aquatic Mammal: Molecular Characterization, Expression Level, and Ligand Profiling in Baikal Seal (Pusa sibirica) Toxicol. Sci., November 1, 2006; 94(1): 57 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. N. C. Gropp, D. L. Greger, C. Morel, S. Sauter, and J. W. Blum Nuclear receptor and nuclear receptor target gene messenger ribonucleic acid levels at different sites of the gastrointestinal tract and in liver of healthy dogs J Anim Sci, October 1, 2006; 84(10): 2684 - 2691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding, K. Lichti, I. Kim, F. J. Gonzalez, and J. L. Staudinger Regulation of Constitutive Androstane Receptor and Its Target Genes by Fasting, cAMP, Hepatocyte Nuclear Factor {alpha}, and the Coactivator Peroxisome Proliferator-activated Receptor {gamma} Coactivator-1{alpha} J. Biol. Chem., September 8, 2006; 281(36): 26540 - 26551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chu, M. Miyazaki, W. C. Man, and J. M. Ntambi Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation. Mol. Cell. Biol., September 1, 2006; 26(18): 6786 - 6798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Slitt, N. J. Cherrington, C. D. Fisher, M. Negishi, and C. D. Klaassen INDUCTION OF GENES FOR METABOLISM AND TRANSPORT BY TRANS-STILBENE OXIDE IN LIVERS OF SPRAGUE-DAWLEY AND WISTAR-KYOTO RATS Drug Metab. Dispos., July 1, 2006; 34(7): 1190 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Faucette, T. Sueyoshi, C. M. Smith, M. Negishi, E. L. LeCluyse, and H. Wang Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor J. Pharmacol. Exp. Ther., June 1, 2006; 317(3): 1200 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding, K. Lichti, and J. L. Staudinger The Mycoestrogen Zearalenone Induces CYP3A through Activation of the Pregnane X Receptor Toxicol. Sci., June 1, 2006; 91(2): 448 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lemaire, W. Mnif, J.-M. Pascussi, A. Pillon, F. Rabenoelina, H. Fenet, E. Gomez, C. Casellas, J.-C. Nicolas, V. Cavailles, et al. Identification of New Human Pregnane X Receptor Ligands among Pesticides Using a Stable Reporter Cell System Toxicol. Sci., June 1, 2006; 91(2): 501 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Slitt, N. J. Cherrington, M. Z. Dieter, L. M. Aleksunes, G. L. Scheffer, W. Huang, D. D. Moore, and C. D. Klaassen trans-Stilbene Oxide Induces Expression of Genes Involved in Metabolism and Transport in Mouse Liver via CAR and Nrf2 Transcription Factors Mol. Pharmacol., May 1, 2006; 69(5): 1554 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gong, S. V. Singh, S. P. Singh, Y. Mu, J. H. Lee, S. P. S. Saini, D. Toma, S. Ren, V. E. Kagan, B. W. Day, et al. Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells Mol. Endocrinol., February 1, 2006; 20(2): 279 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Miki, T. Suzuki, K. Kitada, N. Yabuki, R. Shibuya, T. Moriya, T. Ishida, N. Ohuchi, B. Blumberg, and H. Sasano Expression of the Steroid and Xenobiotic Receptor and Its Possible Target Gene, Organic Anion Transporting Polypeptide-A, in Human Breast Carcinoma Cancer Res., January 1, 2006; 66(1): 535 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aouabdi, G. Gibson, and N. Plant TRANSCRIPTIONAL REGULATION OF THE PXR GENE: IDENTIFICATION AND CHARACTERIZATION OF A FUNCTIONAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR {alpha} BINDING SITE WITHIN THE PROXIMAL PROMOTER OF PXR Drug Metab. Dispos., January 1, 2006; 34(1): 138 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Genetically Modified Animals in Endocrinology Endocr. Rev., December 1, 2005; 26(7): 985 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Wolf, S. G. Wood, J. A. Hunt, B. W. Walton-Strong, K. Yasuda, L. Lan, S. X. Duan, Q. Hao, S. A. Wrighton, E. H. Jeffery, et al. ROLE OF THE NUCLEAR RECEPTOR PREGNANE X RECEPTOR IN ACETAMINOPHEN HEPATOTOXICITY Drug Metab. Dispos., December 1, 2005; 33(12): 1827 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dai, N. Chou, L. He, M. A. Gyamfi, A. J. Mendy, A. L. Slitt, C. D. Klaassen, and Y.-J. Y. Wan Retinoid X Receptor {alpha} Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver Mol. Pharmacol., December 1, 2005; 68(6): 1590 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Kruger, J. W. Blum, and D. L. Greger Expression of Nuclear Receptor and Target Genes in Liver and Intestine of Neonatal Calves Fed Colostrum and Vitamin A J Dairy Sci, November 1, 2005; 88(11): 3971 - 3981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Auerbach, M. A. Stoner, S. Su, and C. J. Omiecinski Retinoid X Receptor-{alpha}-Dependent Transactivation by a Naturally Occurring Structural Variant of Human Constitutive Androstane Receptor (NR1I3) Mol. Pharmacol., November 1, 2005; 68(5): 1239 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Mathias, J. Hitti, and J. D. Unadkat P-glycoprotein and breast cancer resistance protein expression in human placentae of various gestational ages Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R963 - R969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Weng, C. C. DiRusso, A. A. Reilly, P. N. Black, and X. Ding Hepatic Gene Expression Changes in Mouse Models with Liver-specific Deletion or Global Suppression of the NADPH-Cytochrome P450 Reductase Gene: MECHANISTIC IMPLICATIONS FOR THE REGULATION OF MICROSOMAL CYTOCHROME P450 AND THE FATTY LIVER PHENOTYPE J. Biol. Chem., September 9, 2005; 280(36): 31686 - 31698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Wyde, S. E. Kirwan, F. Zhang, A. Laughter, H. B. Hoffman, E. Bartolucci-Page, K. W. Gaido, B. Yan, and L. You Di-n-Butyl Phthalate Activates Constitutive Androstane Receptor and Pregnane X Receptor and Enhances the Expression of Steroid-Metabolizing Enzymes in the Liver of Rat Fetuses Toxicol. Sci., August 1, 2005; 86(2): 281 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Mohutsky, D. M. Petullo, and S. A. Wrighton THE USE OF A SUBSTRATE CASSETTE STRATEGY TO IMPROVE THE CAPACITY AND THROUGHPUT OF CYTOCHROME P450 INDUCTION STUDIES IN HUMAN HEPATOCYTES Drug Metab. Dispos., July 1, 2005; 33(7): 920 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maher, X. Cheng, A. L. Slitt, M. Z. Dieter, and C. D. Klaassen INDUCTION OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN FAMILY OF TRANSPORTERS BY CHEMICAL ACTIVATORS OF RECEPTOR-MEDIATED PATHWAYS IN MOUSE LIVER Drug Metab. Dispos., July 1, 2005; 33(7): 956 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding and J. L. Staudinger The Ratio of Constitutive Androstane Receptor to Pregnane X Receptor Determines the Activity of Guggulsterone against the Cyp2b10 Promoter J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 120 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Krasowski, K. Yasuda, L. R. Hagey, and E. G. Schuetz Evolution of the Pregnane X Receptor: Adaptation to Cross-Species Differences in Biliary Bile Salts Mol. Endocrinol., July 1, 2005; 19(7): 1720 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Hartmann, V. Vassileva, and M. Piquette-Miller IMPACT OF ENDOTOXIN-INDUCED CHANGES IN P-GLYCOPROTEIN EXPRESSION ON DISPOSITION OF DOXORUBICIN IN MICE Drug Metab. Dispos., June 1, 2005; 33(6): 820 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, J. Zhang, M. Washington, J. Liu, J. M. Parant, G. Lozano, and D. D. Moore Xenobiotic Stress Induces Hepatomegaly and Liver Tumors via the Nuclear Receptor Constitutive Androstane Receptor Mol. Endocrinol., June 1, 2005; 19(6): 1646 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Fiorucci, C. Clerici, E. Antonelli, S. Orlandi, B. Goodwin, B. M. Sadeghpour, G. Sabatino, G. Russo, D. Castellani, T. M. Willson, et al. Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 604 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Zavacki and P. R. Larsen CARs and Drugs: A Risky Combination Endocrinology, March 1, 2005; 146(3): 992 - 994. [Full Text] [PDF]
|
|
|
|
|
|
M. Qatanani, J. Zhang, and D. D. Moore Role of the Constitutive Androstane Receptor in Xenobiotic-Induced Thyroid Hormone Metabolism Endocrinology, March 1, 2005; 146(3): 995 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jyrkkarinne, B. Windshugel, J. Makinen, M. Ylisirnio, M. Perakyla, A. Poso, W. Sippl, and P. Honkakoski Amino Acids Important for Ligand Specificity of the Human Constitutive Androstane Receptor J. Biol. Chem., February 18, 2005; 280(7): 5960 - 5971. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. M. Stedman, C. Liddle, S. A. Coulter, J. Sonoda, J. G. A. Alvarez, D. D. Moore, R. M. Evans, and M. Downes Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury PNAS, February 8, 2005; 102(6): 2063 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sonoda, L. W. Chong, M. Downes, G. D. Barish, S. Coulter, C. Liddle, C.-H. Lee, and R. M. Evans Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites PNAS, February 8, 2005; 102(6): 2198 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Ding and J. L. Staudinger Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 849 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. St-Pierre, T. Stallmach, A. Freimoser Grundschober, J.-F. Dufour, M. A. Serrano, J. J. G. Marin, Y. Sugiyama, and P. J. Meier Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1505 - R1516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, W. Huang, M. Qatanani, R. M. Evans, and D. D. Moore The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity J. Biol. Chem., November 19, 2004; 279(47): 49517 - 49522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Vyhlidal, P. K. Rogan, and J. S. Leeder Development and Refinement of Pregnane X Receptor (PXR) DNA Binding Site Model Using Information Theory: INSIGHTS INTO PXR-MEDIATED GENE REGULATION J. Biol. Chem., November 5, 2004; 279(45): 46779 - 46786. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Schrag, D. Cui, T. H. Rushmore, M. Shou, B. Ma, and A. D. Rodrigues SULFOTRANSFERASE 1E1 IS A LOW KM ISOFORM MEDIATING THE 3-O-SULFATION OF ETHINYL ESTRADIOL Drug Metab. Dispos., November 1, 2004; 32(11): 1299 - 1303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, J. Zhang, P. Wei, W. T. Schrader, and D. D. Moore Meclizine Is an Agonist Ligand for Mouse Constitutive Androstane Receptor (CAR) and an Inverse Agonist for Human CAR Mol. Endocrinol., October 1, 2004; 18(10): 2402 - 2408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kodama, C. Koike, M. Negishi, and Y. Yamamoto Nuclear Receptors CAR and PXR Cross Talk with FOXO1 To Regulate Genes That Encode Drug-Metabolizing and Gluconeogenic Enzymes Mol. Cell. Biol., September 15, 2004; 24(18): 7931 - 7940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Matheny, R. Y. Ali, X. Yang, and G. M. Pollack EFFECT OF PROTOTYPICAL INDUCING AGENTS ON P-GLYCOPROTEIN AND CYP3A EXPRESSION IN MOUSE TISSUES Drug Metab. Dispos., September 1, 2004; 32(9): 1008 - 1014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Swales and M. Negishi CAR, Driving into the Future Mol. Endocrinol., July 1, 2004; 18(7): 1589 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Podvinec, C. Handschin, R. Looser, and U. A. Meyer Identification of the xenosensors regulating human 5-aminolevulinate synthase PNAS, June 15, 2004; 101(24): 9127 - 9132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maglich, J. Watson, P. J. McMillen, B. Goodwin, T. M. Willson, and J. T. Moore The Nuclear Receptor CAR Is a Regulator of Thyroid Hormone Metabolism during Caloric Restriction J. Biol. Chem., May 7, 2004; 279(19): 19832 - 19838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bombail, K. Taylor, G. G. Gibson, and N. Plant ROLE OF Sp1, C/EBP{alpha}, HNF3, AND PXR IN THE BASAL- AND XENOBIOTIC-MEDIATED REGULATION OF THE CYP3A4 GENE Drug Metab. Dispos., May 1, 2004; 32(5): 525 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Hartley, X. Dai, Y. D. He, E. J. Carlini, B. Wang, S.-e. W. Huskey, R. G. Ulrich, T. H. Rushmore, R. Evers, and D. C. Evans Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression Mol. Pharmacol., May 1, 2004; 65(5): 1159 - 1171. [Abstract] [Full Text]
|
|
|
|
|
|
S. D. Shenoy, T. A. Spencer, N. A. Mercer-Haines, M. Abdolalipour, W. L. Wurster, M. Runge-Morris, and T. A. Kocarek Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous Squalene Metabolite in Primary Cultured Rat Hepatocytes Mol. Pharmacol., May 1, 2004; 65(5): 1302 - 1312. [Abstract] [Full Text]
|
|
|
|
 |
|
 Z. Zhang, P. E. Burch, A. J. Cooney, R. B. Lanz, F. A. Pereira, J. Wu, R. A. Gibbs, G. Weinstock, and D. A. Wheeler Genomic Analysis of the Nuclear Receptor Family: New Insights Into Structure, Regulation, and Evolution From the Rat Genome Genome Res., April 1, 2004; 14(4): 580 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Stedman, G. Robertson, S. Coulter, and C. Liddle Feed-forward Regulation of Bile Acid Detoxification by CYP3A4: STUDIES IN HUMANIZED TRANSGENIC MICE J. Biol. Chem., March 19, 2004; 279(12): 11336 - 11343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. S. Saini, J. Sonoda, L. Xu, D. Toma, H. Uppal, Y. Mu, S. Ren, D. D. Moore, R. M. Evans, and W. Xie A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification Mol. Pharmacol., February 1, 2004; 65(2): 292 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C G Dietrich, A Geier, and R P J Oude Elferink ABC of oral bioavailability: transporters as gatekeepers in the gut Gut, December 1, 2003; 52(12): 1788 - 1795. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Handschin and U. A. Meyer Induction of Drug Metabolism: The Role of Nuclear Receptors Pharmacol. Rev., December 1, 2003; 55(4): 649 - 673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Guo, G. Lambert, M. Negishi, J. M. Ward, H. B. Brewer Jr., S. A. Kliewer, F. J. Gonzalez, and C. J. Sinal Complementary Roles of Farnesoid X Receptor, Pregnane X Receptor, and Constitutive Androstane Receptor in Protection against Bile Acid Toxicity J. Biol. Chem., November 14, 2003; 278(46): 45062 - 45071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Teng, V. Jekerle, and M. Piquette-Miller INDUCTION OF ABCC3 (MRP3) BY PREGNANE X RECEPTOR ACTIVATORS Drug Metab. Dispos., November 1, 2003; 31(11): 1296 - 1299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Cherrington, A. L. Slitt, J. M. Maher, X.-X. Zhang, J. Zhang, W. Huang, Y.-J. Y. Wan, D. D. Moore, and C. D. Klaassen INDUCTION OF MULTIDRUG RESISTANCE PROTEIN 3 (MRP3) IN VIVO IS INDEPENDENT OF CONSTITUTIVE ANDROSTANE RECEPTOR Drug Metab. Dispos., November 1, 2003; 31(11): 1315 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Fraser, A. Zumsteg, and U. A. Meyer Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Activate a Drug-responsive Enhancer of the Murine 5-Aminolevulinic Acid Synthase Gene J. Biol. Chem., October 10, 2003; 278(41): 39392 - 39401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chen, J. L. Staudinger, and C. D. Klaassen NUCLEAR RECEPTOR, PREGNANE X RECEPTOR, IS REQUIRED FOR INDUCTION OF UDP-GLUCURONOSYLTRANSFERASES IN MOUSE LIVER BY PREGNENOLONE-16{alpha}-CARBONITRILE Drug Metab. Dispos., July 1, 2003; 31(7): 908 - 915. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Rosenfeld, R. Vargas Jr., W. Xie, and R. M. Evans Genetic Profiling Defines the Xenobiotic Gene Network Controlled by the Nuclear Receptor Pregnane X Receptor Mol. Endocrinol., July 1, 2003; 17(7): 1268 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Kliewer The Nuclear Pregnane X Receptor Regulates Xenobiotic Detoxification J. Nutr., July 1, 2003; 133(7): 2444S - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Auerbach, R. Ramsden, M. A. Stoner, C. Verlinde, C. Hassett, and C. J. Omiecinski Alternatively spliced isoforms of the human constitutive androstane receptor Nucleic Acids Res., June 15, 2003; 31(12): 3194 - 3207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Maglich, D. J. Parks, L. B. Moore, J. L. Collins, B. Goodwin, A. N. Billin, C. A. Stoltz, S. A. Kliewer, M. H. Lambert, T. M. Willson, et al. Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes J. Biol. Chem., May 2, 2003; 278(19): 17277 - 17283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Staudinger, A. Madan, K. M. Carol, and A. Parkinson Regulation of Drug Transporter Gene Expression by Nuclear Receptors Drug Metab. Dispos., May 1, 2003; 31(5): 523 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Xie, M.-F. Yeuh, A. Radominska-Pandya, S. P. S. Saini, Y. Negishi, B. S. Bottroff, G. Y. Cabrera, R. H. Tukey, and R. M. Evans Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor PNAS, April 1, 2003; 100(7): 4150 - 4155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, J. Zhang, S. S. Chua, M. Qatanani, Y. Han, R. Granata, and D. D. Moore Induction of bilirubin clearance by the constitutive androstane receptor (CAR) PNAS, April 1, 2003; 100(7): 4156 - 4161. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dussault, H.-D. Yoo, M. Lin, E. Wang, M. Fan, A. K. Batta, G. Salen, S. K. Erickson, and B. M. Forman Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance PNAS, February 4, 2003; 100(3): 833 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Goodwin, K. C. Gauthier, M. Umetani, M. A. Watson, M. I. Lochansky, J. L. Collins, E. Leitersdorf, D. J. Mangelsdorf, S. A. Kliewer, and J. J. Repa Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor PNAS, January 7, 2003; 100(1): 223 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Kliewer, B. Goodwin, and T. M. Willson The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism Endocr. Rev., October 1, 2002; 23(5): 687 - 702. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
