![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Vol. 63, Issue 5, 1059-1066, May 2003
5 Mediates
Short-Term Effects of Nicotine in Vivo
Division of Neuroscience (R.S., R.S.B., M.D.B.), Department of
Molecular and Human Genetics (A.O.-U., A.B., R.P.), Baylor College of
Medicine, Houston, Texas; and Genetics Institute, Tel-Aviv Sourasky
Medical Center and Sackler Faculty of Medicine, Tel-Aviv, Israel
(A.O.-U.)
Nicotine, acting at pentameric neuronal nicotinic acetylcholine
receptors (nAChRs), is the primary addictive component in tobacco. At
low doses, it affects attention, learning, memory, anxiety,
cardiovascular responses, thermoregulation, and nociception. At high
doses, nicotine produces more drastic behaviors and eventually induces
tonic-clonic seizures in rodents. In mammals, several subunits of the
nAChRs have been cloned, including eight 
and three 
subunits. To
study the physiological role of the 5 subunit, we have generated
5-deficient mice. These mice have a generally healthy appearance and
are normal in a standard battery of behavioral tests. However, the
sensitivity of 5 mutant mice to nicotine-induced behaviors and
seizures is dramatically reduced compared with their wild-type
littermates. These animals have a normal brain anatomy and normal
levels of mRNA for other nAChR subunits, namely 4, 6, 7, 2,
and 4. In addition, 125I-epibatidine and
[125I]-bungarotoxin binding in the brains of
5-deficient mice is normal. Together, these results suggest a direct
involvement of the 5 subunit in the observed phenotypes.
This article has been cited by other articles:
|
|
 |
|
  S. M. Kassam, P. M. Herman, N. M. Goodfellow, N. C. Alves, and E. K. Lambe Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors J. Neurosci., August 27, 2008; 28(35): 8756 - 8764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. De Biasi and R. Salas Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal Experimental Biology and Medicine, August 1, 2008; 233(8): 917 - 929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kuryatov, J. Onksen, and J. Lindstrom Roles of Accessory Subunits in {alpha}4{beta}2* Nicotinic Receptors Mol. Pharmacol., July 1, 2008; 74(1): 132 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Arredondo, A. I. Chernyavsky, D. L. Jolkovsky, K. E. Pinkerton, and S. A. Grando Receptor-mediated tobacco toxicity: acceleration of sequential expression of {alpha}5 and {alpha}7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke FASEB J, May 1, 2008; 22(5): 1356 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Jackson, B. R. Martin, J. P. Changeux, and M. I. Damaj Differential Role of Nicotinic Acetylcholine Receptor Subunits in Physical and Affective Nicotine Withdrawal Signs J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 302 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kedmi and A. Orr-Urtreger Expression changes in mouse brains following nicotine-induced seizures: the modulation of transcription factor networks Physiol Genomics, August 20, 2007; 30(3): 242 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ferezou, E. L. Hill, B. Cauli, N. Gibelin, T. Kaneko, J. Rossier, and B. Lambolez Extensive Overlap of Mu-Opioid and Nicotinic Sensitivity in Cortical Interneurons Cereb Cortex, August 1, 2007; 17(8): 1948 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Fischer, A. Orr-Urtreger, L. W Role, and S. Huck Selective deletion of the {alpha}5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse J. Physiol., February 15, 2005; 563(1): 119 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Salas, F. Pieri, and M. De Biasi Decreased Signs of Nicotine Withdrawal in Mice Null for the {beta}4 Nicotinic Acetylcholine Receptor Subunit J. Neurosci., November 10, 2004; 24(45): 10035 - 10039. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Chernyavsky, J. Arredondo, L. M. Marubio, and S. A. Grando Differential regulation of keratinocyte chemokinesis and chemotaxis through distinct nicotinic receptor subtypes J. Cell Sci., November 1, 2004; 117(23): 5665 - 5679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Salminen, K. L. Murphy, J. M. McIntosh, J. Drago, M. J. Marks, A. C. Collins, and S. R. Grady Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice Mol. Pharmacol., June 1, 2004; 65(6): 1526 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kedmi, A. L. Beaudet, and A. Orr-Urtreger Mice lacking neuronal nicotinic acetylcholine receptor {beta}4-subunit and mice lacking both {alpha}5- and {beta}4-subunits are highly resistant to nicotine-induced seizures Physiol Genomics, April 13, 2004; 17(2): 221 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Salas, F. Pieri, B. Fung, J. A. Dani, and M. De Biasi Altered Anxiety-Related Responses in Mutant Mice Lacking the {beta}4 Subunit of the Nicotinic Receptor J. Neurosci., July 16, 2003; 23(15): 6255 - 6263. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
