![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Department of Pharmacology and Toxicology, Queen's University, Kingston, Ontario, Canada
Cyclic AMP (cAMP) and cGMP regulate a myriad of cellular functions, such as metabolism, contractility, motility, and transcription in virtually all cell types, including those of the cardiovascular system. Considerable effort over the last 20 years has allowed identification of the cellular components involved in the synthesis of cyclic nucleotides, as well as effectors of cyclic nucleotide-mediated signaling. More recently, a central role for cyclic nucleotide phosphodiesterase (PDE) has also been elaborated in many cell types, including those involved in regulating the activities of the cardiovascular system. In this review, we introduce the PDE families whose members are expressed in cells of the cardiovascular system including cardiomyocytes, vascular smooth muscle cells, and vascular endothelial cells. Because cell behavior is a dynamic process influenced by numerous factors, we will attempt to emphasize how changes in the activity, expression, and targeting of PDE influence cyclic nucleotide-mediated regulation of the behavior of these cells.
Address correspondence to: Dr. Donald H. Maurice, Heart and Stroke Foundation of Ontario Career Investigator, Department of Pharmacology and Toxicology, Botterell Hall, A215, Queen's University, Kingston, Ontario, Canada, K7L 3N6. E-mail: mauriced{at}post.queensu.ca
This article has been cited by other articles:
|
|
 |
|
  J. W. Gordon, C. Pagiatakis, J. Salma, M. Du, J. J. Andreucci, J. Zhao, G. Hou, R. L. Perry, Q. Dan, D. Courtman, et al. Protein Kinase A-regulated Assembly of a MEF2{middle dot}HDAC4 Repressor Complex Controls c-Jun Expression in Vascular Smooth Muscle Cells J. Biol. Chem., July 10, 2009; 284(28): 19027 - 19042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wolk, W. B. Smith, J. M. Neutel, J. Rubino, D. Xuan, J. Mancuso, J. Gilbert, and M. L. Pressler Blood Pressure Lowering Effects of a New Long-Acting Inhibitor of Phosphodiesterase 5 in Patients With Mild to Moderate Hypertension Hypertension, June 1, 2009; 53(6): 1091 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Adderley, E. A. Dufaux, M. Sridharan, E. A. Bowles, M. S. Hanson, A. H. Stephenson, M. L. Ellsworth, and R. S. Sprague Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1617 - H1624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Berggreen, A. Gormand, B. Omar, E. Degerman, and O. Goransson Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E635 - E646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Raymond, R. L. Carter, C. A. Ward, and D. H. Maurice Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes Am J Physiol Heart Circ Physiol, February 1, 2009; 296(2): H263 - H271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Vinogradova, S. Sirenko, A. E. Lyashkov, A. Younes, Y. Li, W. Zhu, D. Yang, A. M. Ruknudin, H. Spurgeon, and E. G. Lakatta Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases Circ. Res., April 11, 2008; 102(7): 761 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Netherton, J. A. Sutton, L. S. Wilson, R. L. Carter, and D. H. Maurice Both Protein Kinase A and Exchange Protein Activated by cAMP Coordinate Adhesion of Human Vascular Endothelial Cells Circ. Res., October 12, 2007; 101(8): 768 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.-G. Kerfant, D. Zhao, I. Lorenzen-Schmidt, L. S. Wilson, S. Cai, S. R. W. Chen, D. H. Maurice, and P. H. Backx PI3K{gamma} Is Required for PDE4, not PDE3, Activity in Subcellular Microdomains Containing the Sarcoplasmic Reticular Calcium ATPase in Cardiomyocytes Circ. Res., August 17, 2007; 101(4): 400 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Perkins, M. Taniguchi, D. O. Warner, E. N. Chini, and K. A. Jones Reduction in soluble guanylyl cyclase-specific activity following prolonged treatment of porcine pulmonary artery with nitric oxide Am J Physiol Lung Cell Mol Physiol, July 1, 2007; 293(1): L84 - L95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, J. Quilley, D. C. Montrose, S. Rajagopalan, Q. Guan, and C. J. Smith Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2973 - H2981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Houslay, G. S. Baillie, and D. H. Maurice cAMP-Specific Phosphodiesterase-4 Enzymes in the Cardiovascular System: A Molecular Toolbox for Generating Compartmentalized cAMP Signaling Circ. Res., April 13, 2007; 100(7): 950 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Palmer, S. L. Jimmo, D. R. Raymond, L. S. Wilson, R. L. Carter, and D. H. Maurice Protein Kinase A Phosphorylation of Human Phosphodiesterase 3B Promotes 14-3-3 Protein Binding and Inhibits Phosphatase-catalyzed Inactivation J. Biol. Chem., March 30, 2007; 282(13): 9411 - 9419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stefan, B. Wiesner, G. S. Baillie, R. Mollajew, V. Henn, D. Lorenz, J. Furkert, K. Santamaria, P. Nedvetsky, C. Hundsrucker, et al. Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D Is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells J. Am. Soc. Nephrol., January 1, 2007; 18(1): 199 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Murray, H. H. Patel, R. Y. S. Suda, S. Zhang, P. A. Thistlethwaite, J. X.-J. Yuan, and P. A. Insel Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1 Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L294 - L303. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Bevers, E. E. van Faassen, T. D. Vuong, Z. Ni, P. Boer, H. A. Koomans, B. Braam, N. D. Vaziri, and J. A. Joles Low albumin levels increase endothelial NO production and decrease vascular NO sensitivity Nephrol. Dial. Transplant., December 1, 2006; 21(12): 3443 - 3449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fischmeister, L. R.V. Castro, A. Abi-Gerges, F. Rochais, J. Jurevicius, J. Leroy, and G. Vandecasteele Compartmentation of Cyclic Nucleotide Signaling in the Heart: The Role of Cyclic Nucleotide Phosphodiesterases Circ. Res., October 13, 2006; 99(8): 816 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Bender and J. A. Beavo Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use Pharmacol. Rev., September 1, 2006; 58(3): 488 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mullershausen, A. Lange, E. Mergia, A. Friebe, and D. Koesling Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways Mol. Pharmacol., June 1, 2006; 69(6): 1969 - 1974. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R.V. Castro, I. Verde, D. M.F. Cooper, and R. Fischmeister Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes Circulation, May 9, 2006; 113(18): 2221 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. MacPherson, T. D. Gillespie, H. A. Dunkerley, D. H. Maurice, and B. M. Bennett Inhibition of Phosphodiesterase 5 Selectively Reverses Nitrate Tolerance in the Venous Circulation J. Pharmacol. Exp. Ther., April 1, 2006; 317(1): 188 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Busch, H. Liu, A. R. Graveline, and K. D. Bloch Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L747 - L753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Bornfeldt Nuclear Signaling in Smooth Muscle Cells: Cyclic Nucleotide Phosphodiesterase 1A Moves In Circ. Res., March 31, 2006; 98(6): 720 - 722. [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Teixeira, F. B. M. Priviero, and R. C. Webb Differential Effects of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Vardenafil, and Tadalafil in Rat Aorta J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 654 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Giembycz Phosphodiesterase-4: Selective and Dual-Specificity Inhibitors for the Therapy of Chronic Obstructive Pulmonary Disease Proceedings of the ATS, November 1, 2005; 2(4): 326 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumoto, T. Kobayashi, K. Wakabayashi, and K. Kamata Cilostazol improves endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from diabetic rats Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1933 - H1940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumoto, K. Wakabayashi, T. Kobayashi, and K. Kamata Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2234 - H2243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Brunton A positive feedback loop contributes to the deleterious effects of angiotensin PNAS, October 11, 2005; 102(41): 14483 - 14484. [Full Text] [PDF]
|
|
|
|
|
|
H. S. Elbatarny and D. H. Maurice Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E695 - E702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gamboa, R. Abraham, A. Diedrich, C. Shibao, S. Y. Paranjape, G. Farley, and I. Biaggioni Role of Adenosine and Nitric Oxide on the Mechanisms of Action of Dipyridamole Stroke, October 1, 2005; 36(10): 2170 - 2175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Lynch, G. S. Baillie, A. Mohamed, X. Li, C. Maisonneuve, E. Klussmann, G. van Heeke, and M. D. Houslay RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with {beta}Arrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the {beta}2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells J. Biol. Chem., September 30, 2005; 280(39): 33178 - 33189. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Landa Jr., M. Harbeck, K. Kaihara, O. Chepurny, K. Kitiphongspattana, O. Graf, V. O. Nikolaev, M. J. Lohse, G. G. Holz, and M. W. Roe Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 {beta}-Cell Line J. Biol. Chem., September 2, 2005; 280(35): 31294 - 31302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Tilley and D. H. Maurice Vascular Smooth Muscle Cell Phenotype-Dependent Phosphodiesterase 4D Short Form Expression: Role of Differential Histone Acetylation on cAMP-Regulated Function Mol. Pharmacol., September 1, 2005; 68(3): 596 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Houslay The Long and Short of Vascular Smooth Muscle Phosphodiesterase-4 As a Putative Therapeutic Target Mol. Pharmacol., September 1, 2005; 68(3): 563 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. D'Andrea, Y. Qiu, D. Haynes-Johnson, S. Bhattacharjee, P. Kraft, and S. Lundeen Expression of PDE11A in Normal and Malignant Human Tissues J. Histochem. Cytochem., July 1, 2005; 53(7): 895 - 903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Wallace, L. A. Johnston, E. Huston, D. MacMaster, T. M. Houslay, Y.-F. Cheung, L. Campbell, J. E. Millen, R. A. Smith, I. Gall, et al. Identification and Characterization of PDE4A11, a Novel, Widely Expressed Long Isoform Encoded by the Human PDE4A cAMP Phosphodiesterase Gene Mol. Pharmacol., June 1, 2005; 67(6): 1920 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ding, J.-i. Abe, H. Wei, Q. Huang, R. A. Walsh, C. A. Molina, A. Zhao, J. Sadoshima, B. C. Blaxall, B. C. Berk, et al. Functional Role of Phosphodiesterase 3 in Cardiomyocyte Apoptosis: Implication in Heart Failure Circulation, May 17, 2005; 111(19): 2469 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Barrett, D. J. Triggle, M. J.A. Walker, and D. H. Maurice Mechanism of Tissue-Selective Drug Action in the Cardiovascular System Mol. Interv., April 1, 2005; 5(2): 84 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Netherton and D. H. Maurice Vascular Endothelial Cell Cyclic Nucleotide Phosphodiesterases and Regulated Cell Migration: Implications in Angiogenesis Mol. Pharmacol., January 1, 2005; 67(1): 263 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Matsumoto, K. Wakabayashi, T. Kobayashi, and K. Kamata Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery Am J Physiol Heart Circ Physiol, September 1, 2004; 287(3): H1064 - H1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaugg and M. C. Schaub Cellular mechanisms in sympatho-modulation of the heart Br. J. Anaesth., July 1, 2004; 93(1): 34 - 52. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
