MolPharm Over 1500 Individual Drug Articles!

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

0026-895X/04/6503-479-487$20.00
Mol Pharmacol 65:479-487, 2004

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eraly, S. A.
Right arrow Articles by Nigam, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eraly, S. A.
Right arrow Articles by Nigam, S. K.
Minireview

The Molecular Pharmacology of Organic Anion Transporters: from DNA to FDA?

Satish A. Eraly, Kevin T. Bush, Rosemary V. Sampogna, Vibha Bhatnagar, and Sanjay K. Nigam

Departments of Medicine (S.A.E., K.T.B., R.V.S, S.K.N.), Family Medicine (V.B.), Pediatrics (S.K.N.), and Cellular and Molecular Medicine (S.K.N.), University of California, San Diego, and the Veterans Affairs Hospital, La Jolla, California

Renal organic anion secretion has been implicated in numerous clinically significant drug interactions and adverse reactions, indicating the importance of a detailed understanding of this pathway for the development of optimum therapeutics. With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic anion secretion has entered the molecular age. In this review, we focus on various aspects of the molecular biology and pharmacology of the OATs, including discussion of their structural biology, genomic organization in pairs, developmental regulation, toxicology, and pharmacogenetics. We propose functional, pathophysiological, and evolutionary hypotheses to help explain recent experimental and genomic data.

Received September 3, 2003; accepted October 3, 2003

Address correspondence to: Sanjay K. Nigam, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0693, E-mail: snigam{at}ucsd.edu




This article has been cited by other articles:


Home page
 Physiol. GenomicsHome page
S. A. Eraly, V. Vallon, T. Rieg, J. A. Gangoiti, W. R. Wikoff, G. Siuzdak, B. A. Barshop, and S. K. Nigam
Multiple organic anion transporters contribute to net renal excretion of uric acid
Physiol Genomics, April 21, 2008; 33(2): 180 - 192.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Vallon, T. Rieg, S. Y. Ahn, W. Wu, S. A. Eraly, and S. K. Nigam
Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F867 - F873.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. M. Truong, G. Kaler, A. Khandelwal, P. W. Swaan, and S. K. Nigam
Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination
J. Biol. Chem., March 28, 2008; 283(13): 8654 - 8663.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Kaler, D. M. Truong, A. Khandelwal, M. Nagle, S. A. Eraly, P. W. Swaan, and S. K. Nigam
Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs: POTENTIAL REMOTE SENSING BY OAT FAMILY MEMBERS
J. Biol. Chem., August 17, 2007; 282(33): 23841 - 23853.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
F. Zhou, M. Hong, and G. You
Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E57 - E61.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Hong, F. Zhou, K. Lee, and G. You
The Putative Transmembrane Segment 7 of Human Organic Anion Transporter hOAT1 Dictates Transporter Substrate Binding and Stability
J. Pharmacol. Exp. Ther., March 1, 2007; 320(3): 1209 - 1215.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. L. Perry, N. Dembla-Rajpal, L. A. Hall, and J. B. Pritchard
A Three-dimensional Model of Human Organic Anion Transporter 1: AROMATIC AMINO ACIDS REQUIRED FOR SUBSTRATE TRANSPORT
J. Biol. Chem., December 8, 2006; 281(49): 38071 - 38079.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Eraly, V. Vallon, D. A. Vaughn, J. A. Gangoiti, K. Richter, M. Nagle, J. C. Monte, T. Rieg, D. M. Truong, J. M. Long, et al.
Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice
J. Biol. Chem., February 24, 2006; 281(8): 5072 - 5083.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Sekine, H. Miyazaki, and H. Endou
Molecular physiology of renal organic anion transporters
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F251 - F261.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
S. A. Eraly, J. C. Monte, and S. K. Nigam
Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters
Physiol Genomics, June 17, 2004; 18(1): 12 - 24.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 2004 by the American Society for Pharmacology and Experimental Therapeutics