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PERSPECTIVE

Ca²⁺ Regulation of Inositol 1,4,5-trisphosphate Receptors: Can Ca²⁺ Function without Calmodulin?

Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

All Ca²⁺ channels are regulated by Ca²⁺, a feature that allows them to respond to their own activity and to the activities of neighboring Ca²⁺ channels. Inhibition by Ca²⁺ protects cells from potentially hazardous increases in cytosolic [Ca²⁺], and stimulation can mediate facilitation and regenerative propagation of Ca²⁺ signals. Calmodulin is emerging as a key player in regulation of Ca²⁺ channels by Ca²⁺, but its role is more complex and more beautiful than might have been imagined.

Address correspondence to: Colin W. Taylor, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK. E-mail: cwt1000{at}cam.ac.uk

This article has been cited by other articles:

				J. K. Foskett, C. White, K.-H. Cheung, and D.-O. D. Mak Inositol Trisphosphate Receptor Ca2+ Release Channels Physiol Rev, April 1, 2007; 87(2): 593 - 658. [Abstract] [Full Text] [PDF]