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Ca²⁺ Channels As Integrators of G Protein-Mediated Signaling in Neurons

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York

The observations from Dunlap and Fischbach that transmitter-mediated shortening of the duration of action potentials could be caused by a decrease in calcium conductance led to numerous studies of the mechanisms of modulation of voltage-dependent calcium channels. Calcium channels are well known targets for inhibition by receptor-G protein pathways, and multiple forms of inhibition have been described. Inhibition of Ca²⁺ channels can be mediated by G protein -subunits or by kinases, such as protein kinase C and tyrosine kinases. In the last few years, it has been shown that integration of G protein signaling can take place at the level of the calcium channel by regulation of the interaction of the channel pore-forming subunit with different cellular proteins.

Address correspondence to: María A. Diversé-Pierluissi, Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1603, New York, NY 10029. E-mail: maria.diverse{at}mssm.edu

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