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Perspective

Agonists at µ-Opioid Receptors Spin the Wheels to Keep the Action Going

Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland

A study in this issue of Molecular Pharmacology on agonist-induced internalization of µ-opioid receptors during long-term opiate drug exposure is discussed. The study demonstrates the critical role of re-cycling of reactivated µ receptors back to the plasma membrane for the maintenance of agonist signaling during long-term opiate exposure.

Address correspondence to: Brian M. Cox, Department of Pharmacology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda MD 20814. E-mail: bcox{at}usuhs.mil

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				D. Liao, O. O. Grigoriants, H. H. Loh, and P.-Y. Law Agonist-Dependent Postsynaptic Effects of Opioids on Miniature Excitatory Postsynaptic Currents in Cultured Hippocampal Neurons J Neurophysiol, February 1, 2007; 97(2): 1485 - 1494. [Abstract] [Full Text] [PDF]