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Molecular Pharmacology Fast Forward
First published on December 16, 2004; DOI: 10.1124/mol.104.010348

0026-895X/05/6703-583-584$20.00
Mol Pharmacol 67:583-584, 2005

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PERSPECTIVE

An Orphan Receptor Adopted by a Family of Transmitters

Olivier Civelli

Department of Pharmacology and Developmental and Cell Biology, University of California, Irvine, Irvine, California

A tenet of pharmacology states that a receptor must be selective for and bind its natural ligand with high affinity. Recently discovered ligands of some deorphanized G protein-coupled receptors challenge this concept.

Received December 15, 2004; accepted December 16, 2004

Address correspondence to: Olivier Civelli, Department of Pharmacology, University of California, Irvine, Med Surge II, Room 369, Irvine, CA 92697-4625. E-mail: ocivelli{at}uci.edu






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