MolPharm xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
 QUICK SEARCH:   [advanced]


     


Molecular Pharmacology Fast Forward
First published on December 8, 2004; DOI: 10.1124/mol.104.008888


0026-895X/05/6703-714-720$20.00
Mol Pharmacol 67:714-720, 2005

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow All Versions of this Article:
mol.104.008888v1
mol.104.008888v2
67/3/714    most recent
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lahvis, G. P.
Right arrow Articles by Bradfield, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lahvis, G. P.
Right arrow Articles by Bradfield, C. A.
ORIGINAL ARTICLE

The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse{boxs}

Garet P. Lahvis, Robert W. Pyzalski, Edward Glover, Henry C. Pitot, Matthew K. McElwee, and Christopher A. Bradfield

Departments of Surgery (G.P.L., M.K.M.) and Radiology (R.W.P.) and McArdle Laboratory for Cancer Research (E.G., H.C.P., C.A.B.), University of Wisconsin Medical School, Madison, Wisconsin

Abstract

A developmental role for the Ahr locus has been indicated by the observation that mice harboring a null allele display a portocaval vascular shunt throughout life. To define the ontogeny and determine the identity of this shunt, we developed a visualization approach in which three-dimensional (3D) images of the developing liver vasculature are generated from serial sections. Applying this 3D visualization approach at multiple developmental times allowed us to demonstrate that the portocaval shunt observed in Ahr-null mice is the remnant of an embryonic structure and is not acquired after birth. We observed that the shunt is found in late-stage wild-type embryos but closes during the first 48 h of postnatal life. In contrast, the same structure fails to close in Ahr-null mice and remains open throughout adulthood. The ontogeny of this shunt, along with its 3D position, allowed us to conclude that this shunt is a patent developmental structure known as the ductus venosus (DV). Upon searching for a physiological cause of the patent DV, we observed that during the first 48 h, most major hepatic veins, such as the portal and umbilical veins, normally decrease in diameter but do not change in Ahr-null mice. This observation suggests that failure of the DV to close may be the consequence of increased blood pressure or a failure in vasoconstriction in the developing liver.


Received November 2, 2004; accepted December 7, 2004

Address correspondence to: Christopher A. Bradfield, McArdle Laboratory for Cancer Research, 1400 University Ave., Madison, WI 53706. E-mail: bradfield{at}oncology.wisc.edu




This article has been cited by other articles:


Home page
J Biol RhythmsHome page
M. Mukai, T.-M. Lin, R. E. Peterson, P. S. Cooke, and S. A. Tischkau
Behavioral Rhythmicity of Mice Lacking AhR and Attenuation of Light-Induced Phase Shift by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin
J Biol Rhythms, June 1, 2008; 23(3): 200 - 210.
[Abstract] [PDF]


Home page
Mol. Pharmacol.Home page
N. Dragin, Z. Shi, R. Madan, C. L. Karp, M. A. Sartor, C. Chen, F. J. Gonzalez, and D. W. Nebert
Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse
Mol. Pharmacol., June 1, 2008; 73(6): 1844 - 1856.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
B. J. McMillan and C. A. Bradfield
The Aryl Hydrocarbon Receptor sans Xenobiotics: Endogenous Function in Genetic Model Systems
Mol. Pharmacol., September 1, 2007; 72(3): 487 - 498.
[Abstract] [Full Text] [PDF]


Home page
Toxicol SciHome page
A. B. Okey
An Aryl Hydrocarbon Receptor Odyssey to the Shores of Toxicology: The Deichmann Lecture, International Congress of Toxicology-XI
Toxicol. Sci., July 1, 2007; 98(1): 5 - 38.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
W. A. Fritz, T.-M. Lin, R. D. Cardiff, and R. E. Peterson
The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice
Carcinogenesis, February 1, 2007; 28(2): 497 - 505.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
B. J. McMillan and C. A. Bradfield
The Aryl hydrocarbon receptor is activated by modified low-density lipoprotein
PNAS, January 23, 2007; 104(4): 1412 - 1417.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
N. Dragin, T. P. Dalton, M. L. Miller, H. G. Shertzer, and D. W. Nebert
For Dioxin-induced Birth Defects, Mouse or Human CYP1A2 in Maternal Liver Protects whereas Mouse CYP1A1 and CYP1B1 Are Inconsequential
J. Biol. Chem., July 7, 2006; 281(27): 18591 - 18600.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
E. E. Dunham, E. A. Stevens, E. Glover, and C. A. Bradfield
The Aryl Hydrocarbon Receptor Signaling Pathway Is Modified through Interactions with a Kelch Protein
Mol. Pharmacol., July 1, 2006; 70(1): 8 - 15.
[Abstract] [Full Text] [PDF]


Home page
CarcinogenesisHome page
S. Mulero-Navarro, J.M. Carvajal-Gonzalez, M. Herranz, E. Ballestar, M.F. Fraga, S. Ropero, M. Esteller, and P.M. Fernandez-Salguero
The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding
Carcinogenesis, May 1, 2006; 27(5): 1099 - 1104.
[Abstract] [Full Text] [PDF]


Home page
Mol. Pharmacol.Home page
E. B. Harstad, C. A. Guite, T. L. Thomae, and C. A. Bradfield
Liver Deformation in Ahr-Null Mice: Evidence for Aberrant Hepatic Perfusion In Early Development
Mol. Pharmacol., May 1, 2006; 69(5): 1534 - 1541.
[Abstract] [Full Text] [PDF]




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
 Molecular Interventions Drug Metabolism and Disposition

Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics