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First published on January 26, 2005; DOI: 10.1124/mol.105.011429

0026-895X/05/6704-980-982$20.00
Mol Pharmacol 67:980-982, 2005

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Perspective

Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell-Penetrating Peptide Technologies and Pharmacologies

Lee E. Eiden

Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Bethesda, Maryland

Cell-penetrating peptides are amphipathic or cationic oligopeptides able to transport covalently attached cargoes across cell membranes. Peptide aptamers are polypeptide fragments of endogenous proteins that mimic and thus perturb interactions with other cellular proteins. Combining aptamer and CPP technology can generate pharmacological reagents effective in cell culture models and in vivo.

Received January 25, 2005; accepted January 25, 2005

Address correspondence to: Dr. Lee E. Eiden, Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health Intramural Research Program, Building 36, Room 2A-11, 9000 Rockville Pike, Bethesda, MD, 20892. E-mail: eidenl{at}mail.nih.gov




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