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Molecular Pharmacology Fast Forward
First published on May 27, 2005; DOI: 10.1124/mol.105.015263

0026-895X/05/6802-275-278$20.00
Mol Pharmacol 68:275-278, 2005

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Perspective

Double Feature at the Signalplex

Kim A. Neve

Department of Behavioral Neuroscience, Oregon Health & Science University, and Veterans Affairs Medical Center, Portland, Oregon

In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT1 receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT1 receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.

Received May 26, 2005; accepted May 27, 2005

Address correspondence to: Kim A. Neve, VA Medical Center (R&D-30), 3710 SW US Veterans Hospital Rd, Portland, OR 97239-2999. E-mail: nevek{at}ohsu.edu.




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