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Molecular Pharmacology Fast Forward
First published on May 27, 2005; DOI: 10.1124/mol.105.015263

0026-895X/05/6802-275-278$20.00
Mol Pharmacol 68:275-278, 2005

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Perspective

Double Feature at the Signalplex

Kim A. Neve

Department of Behavioral Neuroscience, Oregon Health & Science University, and Veterans Affairs Medical Center, Portland, Oregon

In this issue of Molecular Pharmacology, Oliveras-Reyes et al. (p. 356) describe the agonist-stimulated formation of a caveolin-dependent signalplex that includes both the angiotensin AT1 receptor and the epidermal growth factor receptor, and probably also a number of other signal transduction intermediates. The signalplex is thought to facilitate the action of protein kinases that mediate angiotensin II-induced transactivation of the epidermal growth factor receptor and activation of extracellular signal-regulated kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/desensitization of the AT1 receptor. This work contributes to an emerging view of the complexity and nonlinearity of signaling via G protein-coupled receptors and receptor tyrosine kinases, and of the importance of membrane compartmentalization to signal transduction.

Received for publication May 26, 2005.

Accepted for publication May 27, 2005.

Address correspondence to: Kim A. Neve, VA Medical Center (R&D-30), 3710 SW US Veterans Hospital Rd, Portland, OR 97239-2999. E-mail: nevek{at}ohsu.edu.




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