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Perspective

The _1D-Adrenergic Receptor: Cinderella or Ugly Stepsister

Molecular Cardiology Program, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia

This Perspective focuses on the _1D-adrenergic receptor (AR), the often neglected sibling of the ₁-AR family. This neglect is due in part to its poor cell-surface expression. However, it has recently been shown that dimerization of the _1D-AR with either the _1B-AR or the ₂-AR increases _1D-AR cell-surface expression, and in this issue of Molecular Pharmacology, Hague et al. (p. 45) demonstrate that dimerization of the _1D-AR with the _1B-AR not only leads to increased cell-surface expression but also results in the formation of a novel functional entity.

Address correspondence to: Dr. Robert M. Graham, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, 2010 NSW, Australia. E-mail: b.graham{at}victorchang.unsw.edu.au

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Heterodimers of _1B- and _1D-Adrenergic Receptors Form a Single Functional Entity

Chris Hague, Sarah E. Lee, Zhongjian Chen, Steven C. Prinster, Randy A. Hall, and Kenneth P. Minneman
MolPharm 2006 69: 45-55. [Abstract] [Full Text]