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Molecular Pharmacology, Vol 7, 81-86, Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics

Enhanced Synthesis of Adrenal Dopamine beta-Hydroxylase Induced by Repeated Immobilization in Rats

RICHARD KVETNcaronANSKYacute 1, GEORGE P. GEWIRTZ 1, VIRGINIA K. WEISE 1, and IRWIN J. KOPIN 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

Repeated immobilization of rats results in a striking increase in adrenal medullary dopamine beta-hydroxylase activity. After six periods of immobilization the levels are highest preceding the next immobilization, decrease during the immobilization, and increase upon termination of the immobilization. Six hours after the immobilization the activities return nearly to the preimmobilization levels. Denervation of the adrenal markedly diminishes the increase in dopamine beta-hydroxylase activity that occurs with repeated immobilization. Prior treatment with hexamethonium prevents the decrease in activity during the immobilization interval, whereas the protein synthesis inhibitors actinomycin D and cycloheximide prevent the increase in enzyme activity seen after termination of immobilization. These observations support the view that dopamine beta-hydroxylase is released as a result of neural stimulationn during immobilization and suggest that its increase following cessation of immobilization is a consequence of accelerated synthesis of the enzyme.

Note:
ACKNOWLEDGMENT We would like to thank Mrs. Darina Kvetncaronanská for her excellent technical assistance.

Submitted on July 24, 1970




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Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics