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Molecular Pharmacology, Vol 7, 163-168, Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics

Effect of Hypophysectomy on Adrenal Dopamine beta-Hydroxylase Activity in the Rat

GEORGE P. GEWIRTZ 1, RICHARD KEVETNcaronANSKYacute 1, VIRGINIA K WEISE 1, and IRWIN J. KOPIN 1

1 Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20014

Dopamine beta-hydroxylase activity in the adrenal medulla is decreased 1 week after hypophysectomy. This activity can be restored by treatment with either adrenocorticotropin or dexamethasone. Adrenal denervation also decreases adrenal dopamine beta-hydroxylase activity and prevents elevation of this enzyme in response to immobilization. Intact pituitary-adrenal and neuronal systems are required to maintain normal adrenal dopamine beta-hydroxylase levels nonimmobilized rats and to raise the levels in immobilized rats.

Note:
ACKNOWLEDGMENT We are grateful to Mrs. Darina Kvetncaronanská for her excellent technical assistance.

Submitted on October 3, 1970




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