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Molecular Pharmacology, Vol 7, 605-610, Copyright © 1971 by the American Society for Pharmacology and Experimental Therapeutics

On the Mode of Action of Levallorphan on Escherichia coli: Effects on Cellular Magnesium

M. A. DEVYNCK 1, P. L. BOQUET 1, P. FROMAGEOT 1, and E. J. SIMON 2

1 Service de Biochimie, Centre d'Etudes Nucléaires de Saclay, 91 Gif sur Yvette, France
2 Department of Medicine, New York University Medical Center, New York, New York 10016

Inhibition of the growth of Escherichia coli by levallorphan increased in effectiveness as the medium concentration of Mg++ was decreased. Two molecules of levallorphan were shown to compete with 1 atom of Mg++, presumably on the cell surface. Active transport of Mg++ was altered in the presence of the drug, and this effect could be prevented by high concentrations of Ca++. Reduction of cellular Mg++ content in the presence of levallorphan is suggested to be one possible cause of growth inhibition.

Submitted on April 8, 1971






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