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Perspective

Pharmacology Meets Vesicular Trafficking at a Central Nervous System Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan

The contribution by Micheva et al. (p. 467) in this issue of Molecular Pharmacology adds to our understanding of the action of pregabalin, a drug used for treatment of partial seizures and neuropathic pain. The authors examine the effects of pregabalin on presynaptic function of cultured hippocampal neurons using a powerful technique to follow the trafficking of synaptic vesicles in individual boutons. The study revealed that pregabalin reduces the readily releasable pool of synaptic vesicles in an N-methyl-D-aspartate receptor-dependent manner.

Address correspondence to: Ronald W. Holz, Department of Pharmacology, University of Michigan Medical School, 2301 MSRB III, Ann Arbor, MI 48109-0632. E-mail holz{at}umich.edu

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Pregabalin Reduces the Release of Synaptic Vesicles from Cultured Hippocampal Neurons

Kristina D. Micheva, Charles P. Taylor, and Stephen J Smith
MolPharm 2006 70: 467-476. [Abstract] [Full Text]