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Molecular Pharmacology Fast Forward
First published on February 15, 2007; DOI: 10.1124/mol.107.035196

0026-895X/07/7105-1203-1205$20.00
Mol Pharmacol 71:1203-1205, 2007

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Perspective

The Thrill Can Kill: Murder by Methylation

Sailen Barik

Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, Mobile, Alabama

Why babies of crack-cocaine mothers develop heart problems has always been a mystery. In this issue of Molecular Pharmacology, Zhang et al. (p. 1319) show that a specific methylation occurs at the protein kinase C{epsilon} (PKC{epsilon}) promoter of the babies born of mother rats exposed to cocaine. This reduces the expression of PKC{epsilon}, a naturally cardioprotective enzyme, which provides a plausible molecular mechanism for cardiac failure.

Received February 13, 2007; accepted February 15, 2007

Address correspondence to: Sailen Barik, Department of Biochemistry and Molecular Biology, University of South Alabama, College of Medicine, 307 University Blvd., Mobile, AL 36688-0002. E-mail: sbarik{at}jaguar1.usouthal.edu


Related articles in MolPharm:

Maternal Cocaine Administration Causes an Epigenetic Modification of Protein Kinase C{epsilon} Gene Expression in Fetal Rat Heart
Haitao Zhang, Agus Darwanto, Thomas A. Linkhart, Lawrence C. Sowers, and Lubo Zhang
MolPharm 2007 71: 1319-1328. [Abstract] [Full Text]  





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