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Building a Pharmacological Lexicon: Small Molecule Discovery in Academia

Department of Pharmacology, Pittsburgh Molecular Library Screening Center, University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania (J.S.L.); Molecular Screening Centers Network, Division of Neuroscience and Basic Behavioral Science, National Institute of Mental Health, Bethesda, Maryland (L.S.B.); and Department of Pharmacology, Emory Chemical-Biology Discovery Center, Emory University, Atlanta, Georgia (R.D.)

Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of molecular pharmacology with contemporary high-throughput and high-content screening technologies is essential for the success of these discovery activities. We present some of the challenges and opportunities provided by the Molecular Library Screening Centers Network (MLSCN), which is a National Institutes of Health Roadmap Initiative.

Received for publication February 11, 2007.

Accepted for publication March 29, 2007.

Address correspondence to: John S. Lazo, Department of Pharmacology, Pittsburgh Molecular Library Screening Center, University of Pittsburgh, Biomedical Science Tower 3, Suite 10040, Pittsburgh, PA 15261-0001. E-mail: lazo{at}pitt.edu; Raymond Dingledine, Department of Pharmacology, Emory Chemical-Biology Center, 1510 Clifton Rd., Emory University, Atlanta, GA 30322. E-mail: rdingledine{at}pharm.emory.edu

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