![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin
For more than 30 years, the aryl hydrocarbon receptor [Ah receptor (AHR)] has been extensively scrutinized as the cellular receptor for numerous environmental contaminants, including polychlorinated dioxins, dibenzofurans, and biphenyls. Recent evidence argues that this description is incomplete and perhaps myopic. Ah receptor orthologs have been demonstrated to mediate diverse endogenous functions in our close vertebrate relatives as well as our distant invertebrate ancestors. Moreover, these endogenous functions suggest that xenobiotic toxicity may be best understood in the context of intrinsic AHR physiology. In this literature review, we survey the emerging picture of endogenous AHR biology from work in the vertebrate and invertebrate model systems Mus musculus, Caenorhabditis elegans, and Drosophila melanogaster.
Received for publication April 18, 2007.
Accepted for publication May 29, 2007.
Address correspondence to: Christopher A. Bradfield, 1400 University Avenue, Room 213, Madison, WI 53706. E-mail: bradfield{at}oncology.wisc.edu
This article has been cited by other articles:
|
|
 |
|
  P. C. Boutros, K. A. Bielefeld, R. Pohjanvirta, and P. A. Harper Dioxin-Dependent and Dioxin-Independent Gene Batteries: Comparison of Liver and Kidney in AHR-Null Mice Toxicol. Sci., November 1, 2009; 112(1): 245 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kawajiri, Y. Kobayashi, F. Ohtake, T. Ikuta, Y. Matsushima, J. Mimura, S. Pettersson, R. S. Pollenz, T. Sakaki, T. Hirokawa, et al. Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands PNAS, August 11, 2009; 106(32): 13481 - 13486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Volotinen, J. Maenpaa, E. Kankuri, O. Oksala, O. Pelkonen, M. Nakajima, T. Yokoi, and J. Hakkola Expression of Cytochrome P450 (CYP) Enzymes in Human Nonpigmented Ciliary Epithelial Cells: Induction of CYP1B1 Expression by TCDD Invest. Ophthalmol. Vis. Sci., July 1, 2009; 50(7): 3099 - 3105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nohara, T. Suzuki, K. Ao, H. Murai, Y. Miyamoto, K. Inouye, X. Pan, H. Motohashi, Y. Fujii-Kuriyama, M. Yamamoto, et al. Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-{gamma} production in mice but does not suppress Th2-cytokine production or antibody production Int. Immunol., July 1, 2009; 21(7): 769 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Carvajal-Gonzalez, S. Mulero-Navarro, A. C. Roman, V. Sauzeau, J. M. Merino, X. R. Bustelo, and P. M. Fernandez-Salguero The Dioxin Receptor Regulates the Constitutive Expression of the Vav3 Proto-Oncogene and Modulates Cell Shape and Adhesion Mol. Biol. Cell, March 15, 2009; 20(6): 1715 - 1727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Nebert and C. L. Karp Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology J. Biol. Chem., December 26, 2008; 283(52): 36061 - 36065. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Monteiro, D. Gilot, S. Langouet, and O. Fardel Activation of the Aryl Hydrocarbon Receptor by the Calcium/Calmodulin-Dependent Protein Kinase Kinase Inhibitor 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid (STO-609) Drug Metab. Dispos., December 1, 2008; 36(12): 2556 - 2563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Xiong, R. E. Peterson, and W. Heideman Aryl Hydrocarbon Receptor-Mediated Down-Regulation of Sox9b Causes Jaw Malformation in Zebrafish Embryos Mol. Pharmacol., December 1, 2008; 74(6): 1544 - 1553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Murphy The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 3, 1984-2008 Drug Metab. Dispos., October 1, 2008; 36(10): 1977 - 1982. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dabir, T. E. Marinic, I. Krukovets, and O. I. Stenina Aryl Hydrocarbon Receptor Is Activated by Glucose and Regulates the Thrombospondin-1 Gene Promoter in Endothelial Cells Circ. Res., June 20, 2008; 102(12): 1558 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Dragin, Z. Shi, R. Madan, C. L. Karp, M. A. Sartor, C. Chen, F. J. Gonzalez, and D. W. Nebert Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse Mol. Pharmacol., June 1, 2008; 73(6): 1844 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Roman, D. A. Benitez, J. M. Carvajal-Gonzalez, and P. M. Fernandez-Salguero Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo PNAS, February 5, 2008; 105(5): 1632 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Goldstone, H. M. H. Goldstone, A. M. Morrison, A. Tarrant, S. E. Kern, B. R. Woodin, and J. J. Stegeman Cytochrome P450 1 Genes in Early Deuterostomes (Tunicates and Sea Urchins) and Vertebrates (Chicken and Frog): Origin and Diversification of the CYP1 Gene Family Mol. Biol. Evol., December 1, 2007; 24(12): 2619 - 2631. [Abstract] [Full Text] [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
