QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Related Article All Versions of this Article: mol.107.040055v1 72/4/810    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Related articles in MolPharm Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zeller, C. E. Articles by Dohlman, H. G. Search for Related Content PubMed PubMed Citation Articles by Zeller, C. E. Articles by Dohlman, H. G.

Perspective

Illuminating Gβ₅ Signaling

Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

G proteins are key intermediates in cellular signaling and act in response to a variety of extracellular stimuli. The prevailing paradigm is that G protein subunits form a heterotrimeric complex and function principally at the plasma membrane. However, there is growing evidence for localization at, and signaling by, G proteins at intracellular compartments. Moreover, different cellular pools of G proteins may be composed of distinct subunit subtypes, including some binding partners that function in the place of G protein subunits. An article in this issue of Molecular Pharmacology (Yost et al., p. 812) describes the use of an innovative fluorescent cell imaging technique to study interactions of the G protein β₅ subunit with a panel of G subunits as well as regulator of G protein signaling (RGS) proteins that contain a G-like subdomain. The approach used here provides a new strategy to elucidate the spatial and temporal properties of G proteins, including a growing number of atypical Gβ pairings.

Address correspondence to: Henrik G. Dohlman, Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, 116 Manning Dr., CB 7260, Chapel Hill, NC 27599. E-mail: henrik_dohlman{at}med.unc.edu

Related articles in MolPharm:

Live Cell Analysis of G Protein ₅ Complex Formation, Function, and Targeting

Evan A. Yost, Stacy M. Mervine, Jonathan L. Sabo, Thomas R. Hynes, and Catherine H. Berlot
MolPharm 2007 72: 812-825. [Abstract] [Full Text]