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First published on October 5, 2007; DOI: 10.1124/mol.107.038299

0026-895X/08/7301-12-17$20.00
Mol Pharmacol 73:12-17, 2008

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A Functional Steroid-Binding Element in an ATP-Binding Cassette Multidrug Transporter

Saroj Velamakanni, Tavan Janvilisri, Sanjay Shahi, and Hendrik W. van Veen

Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom

The human breast cancer resistance protein is an ATP-binding cassette (ABC) multidrug transporter that affects the bioavailability of chemotherapeutic drugs and can confer drug resistance on cancer cells. It is the second member of the ABCG subfamily, other members of which are associated with human steroid disorders such as hypercholesterolemia, sitosterolemia, and atherosclerosis. The molecular bases of protein-steroid interactions in ABC transporters are unknown. Here, we identify a steroid-binding element in the membrane domain of ABCG2 with a similarity to steroid hormone/nuclear receptors. The element facilitates steroid hormone binding and mediates modulation of ABCG2 activity. The identification of this element might provide an opportunity for the development of new therapeutic ligands for ABCG2.

Received May 18, 2007; accepted October 5, 2007

Address correspondence to: Dr. Hendrik W. van Veen, Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom. E-mail: hwv20{at}cam.ac.uk






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